@article{6cd02b0cdbdc4e5babcfb934607bd567,
title = "Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5′-hydroxybutitaxel",
abstract = "A highly efficient kinetic resolution of racemic cis-4-(2-tert-butyldimethylsilyloxy-1,1-dimethyl)ethyl-3-tert-butyldimethylsilyloxy-azetidin-2-one with 7-O-triethylsilylbaccatin III was carried out to furnish 10-O-acetyl-5′-hydroxybutitaxel after removal of the silyl protecting groups. The compound was 50% as active as paclitaxel in a tubulin assembly assay and showed significantly decreased activity against MCF7 cell proliferation compared to paclitaxel.",
keywords = "Cytotoxicity, Kinetic resolution, MCF7, NCI/ADR RES, Paclitaxel analogues, Semisynthesis, Tubulin assembly",
author = "Haibo Ge and Jianmei Wang and Kayser, {Margaret M.} and Himes, {Richard H.} and Georg, {Gunda I.}",
note = "Funding Information: The authors wish to thank the National Cancer Institute for financial support of this research (NIH CA82801 and NIH CA105305), NBIF Research Assistantship Initiative, and Tapestry Pharmaceuticals (Boulder, CO) for a generous gift of 10-deacetylbaccatin III. We wish to thank Christopher Schneider for his help with the HPLC analysis. We also thank Jacquelyn K. Huff for her excellent technical assistance. ",
year = "2008",
month = dec,
day = "1",
doi = "10.1016/j.bmcl.2008.10.010",
language = "English",
volume = "18",
pages = "6165--6167",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
number = "23",
}