Abstract
A new DTBP/Mg(NO3)2-mediated bicyclization cascade of o-arylalkynylanilines with secondary arylphosphine oxides has been developed, enabling dual C(sp2)-H functionalization along with the cleavage of the C-N bond. The combination between regioselective P-centered radical-triggered [3 + 2] cyclization and C-centered radical-induced cross-coupling in a one-pot manner delivered 27 examples of tribenzo[b,e,g]phosphindole oxides with generally high regioselectivity. A reasonable mechanism for forming such products involving radical addition-cyclization cascade is proposed.
Original language | English |
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Pages (from-to) | 4512-4515 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 19 |
Issue number | 17 |
DOIs | |
State | Published - Sep 1 2017 |