Abstract
An efficient combination between the Passerini three-component reaction and aldol condensation has been developed for the synthesis of bicyclic isocoumarins with different substituted patterns via solvent-dependent domino pathways. These two operationally friendly methods simultaneously install C-O and C-C bonds in a one-pot manner, allowing the utilization of low-cost and readily accessible 2-formylbenzoic acid, isocyanides, and arylglyoxals. Mechanisms of formation of different substituted isocoumarin derivatives are also proposed.
Original language | English |
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Pages (from-to) | 4504-4507 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 16 |
Issue number | 17 |
DOIs | |
State | Published - Sep 5 2014 |