Synthesis of isocoumarins with different substituted patterns via Passerini-aldol sequence

Guan Hua Ma, Bo Jiang, Xing Jun Tu, Yi Ning, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

An efficient combination between the Passerini three-component reaction and aldol condensation has been developed for the synthesis of bicyclic isocoumarins with different substituted patterns via solvent-dependent domino pathways. These two operationally friendly methods simultaneously install C-O and C-C bonds in a one-pot manner, allowing the utilization of low-cost and readily accessible 2-formylbenzoic acid, isocyanides, and arylglyoxals. Mechanisms of formation of different substituted isocoumarin derivatives are also proposed.

Original languageEnglish
Pages (from-to)4504-4507
Number of pages4
JournalOrganic Letters
Volume16
Issue number17
DOIs
StatePublished - Sep 5 2014

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