Synthesis of Functionalized Chromene and Chroman Derivatives via Cesium Carbonate Promoted Formal [4+2] Annulation of 2'Hydroxychalcones with Allenoates

Hossein Rouh, Yangxue Liu, Nandakumar Katakam, Lilian Pham, Yi-Long Zhu, Guigen Li

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

A new strategy has been established for the synthesis of functionalized chromene and chroman derivatives via a Cs 2 CO 3 -catalyzed domino addition of 2′-hydroxychalcone derivatives with allenoates, which can serve as a general avenue for the construction of multireplaced chromene derivatives. Chemoselectivity of this synthesis was found to depend on substituents on substrates. Good to excellent yields were achieved under simple and mild conditions at room temperature.

Original languageEnglish
Pages (from-to)15372-15379
Number of pages8
JournalDefault journal
Volume83
Issue number24
DOIs
StatePublished - Dec 21 2018

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