Abstract
An effective chiral GAP methodology for preparing α-aminomethyl enaminones through a (R)-CSA-catalyzed asymmetric aza-Baylis-Hillman reaction is reported. Excellent yields and high diastereoselectivity could be obtained under mild conditions and convenient GAP techniques. The confirmations of the absolute configuration of N-phosphonyl imine and chiral enaminone by X-ray diffraction provides an explicit explanation of the chirality mechanism for GAP chemistry.
Original language | English |
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Pages (from-to) | 1125-1131 |
Number of pages | 7 |
Journal | Chemistry - An Asian Journal |
Volume | 15 |
Issue number | 7 |
DOIs | |
State | Published - Apr 1 2020 |
Keywords
- Asymmetric synthesis
- Aza-Baylis-Hillman reaction
- Brønsted Acid Catalysis
- GAP chemistry
- α-Aminomethyl enaminones