Synthesis of d-labeled and unlabeled benzoyloxysuccinimides and application to quantitative analysis of peptides and a protein by isotope differential mass spectrometry

Masoud Zabet-Moghaddam, Aarif L. Shaikh, Lauren B. Jones, Satomi Niwayama

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Benzoyloxysuccinimide and its d 5-labeled version, which react with amino groups in the N-termini and lysine side chains in proteins, were synthesized and applied to quantitative analysis of peptides and a commercially available protein in combination with a MALDI mass spectrometer.

Original languageEnglish
Pages (from-to)4629-4632
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number15
DOIs
StatePublished - Aug 1 2011

Keywords

  • Amino group modifier
  • Mass spectrometry
  • Proteomics
  • Stable isotope-labeling

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