Synthesis of a rationally designed inhibitor of the (s)-adenosyl-l-methionine: Δ24(25)-sterol methyl transferase

De an Guo; W. David Nes

doi:10.1080/00397919508011808

Synthesis of a rationally designed inhibitor of the (s)-adenosyl-l-methionine: Δ²⁴⁽²⁵⁾-sterol methyl transferase

De an Guo, W. David Nes

Chemistry and Biochemistry

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

A facile preparation of the first bisubstrata analog 4,4- dimethyl 14a-methyl 24(R, S)-OMe, 25-dimethyl amino cholest-8-en-3β-o1 3 designed to interfere with the binding of (S)-adenosyl-L-methionine and of the natural sterol substrate to the (S)-adenosyl-L-methionine: Δ²⁴⁽²⁵⁾-sterol methyl transferase is reported here. Confirmation of the identity of the novel side chain modified N-sterol was obtained by ¹H- and ¹³C-NMR.

Original language	English
Pages (from-to)	2623-2630
Number of pages	8
Journal	Synthetic Communications
Volume	25
Issue number	17
DOIs	https://doi.org/10.1080/00397919508011808
State	Published - Sep 1 1995

Access to Document

10.1080/00397919508011808

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Synthesis of a rationally designed inhibitor of the (s)-adenosyl-l-methionine: Δ<sup>24(25)</sup>-sterol methyl transferase'. Together they form a unique fingerprint.

Cite this

@article{450f874ce482470eb29daaf9d3014565,

title = "Synthesis of a rationally designed inhibitor of the (s)-adenosyl-l-methionine: Δ24(25)-sterol methyl transferase",

abstract = "A facile preparation of the first bisubstrata analog 4,4- dimethyl 14a-methyl 24(R, S)-OMe, 25-dimethyl amino cholest-8-en-3β-o1 3 designed to interfere with the binding of (S)-adenosyl-L-methionine and of the natural sterol substrate to the (S)-adenosyl-L-methionine: Δ24(25)-sterol methyl transferase is reported here. Confirmation of the identity of the novel side chain modified N-sterol was obtained by 1H- and 13C-NMR.",

author = "Guo, {De an} and Nes, {W. David}",

year = "1995",

month = sep,

day = "1",

doi = "10.1080/00397919508011808",

language = "English",

volume = "25",

pages = "2623--2630",

journal = "Synthetic Communications",

issn = "0039-7911",

number = "17",

}

TY - JOUR

T1 - Synthesis of a rationally designed inhibitor of the (s)-adenosyl-l-methionine

T2 - Δ24(25)-sterol methyl transferase

AU - Guo, De an

AU - Nes, W. David

PY - 1995/9/1

Y1 - 1995/9/1

N2 - A facile preparation of the first bisubstrata analog 4,4- dimethyl 14a-methyl 24(R, S)-OMe, 25-dimethyl amino cholest-8-en-3β-o1 3 designed to interfere with the binding of (S)-adenosyl-L-methionine and of the natural sterol substrate to the (S)-adenosyl-L-methionine: Δ24(25)-sterol methyl transferase is reported here. Confirmation of the identity of the novel side chain modified N-sterol was obtained by 1H- and 13C-NMR.

AB - A facile preparation of the first bisubstrata analog 4,4- dimethyl 14a-methyl 24(R, S)-OMe, 25-dimethyl amino cholest-8-en-3β-o1 3 designed to interfere with the binding of (S)-adenosyl-L-methionine and of the natural sterol substrate to the (S)-adenosyl-L-methionine: Δ24(25)-sterol methyl transferase is reported here. Confirmation of the identity of the novel side chain modified N-sterol was obtained by 1H- and 13C-NMR.

UR - http://www.scopus.com/inward/record.url?scp=0029115345&partnerID=8YFLogxK

U2 - 10.1080/00397919508011808

DO - 10.1080/00397919508011808

M3 - Article

AN - SCOPUS:0029115345

VL - 25

SP - 2623

EP - 2630

JO - Synthetic Communications

JF - Synthetic Communications

SN - 0039-7911

IS - 17

ER -