TY - JOUR
T1 - Synthesis of a rationally designed inhibitor of the (s)-adenosyl-l-methionine
T2 - Δ24(25)-sterol methyl transferase
AU - Guo, De an
AU - Nes, W. David
N1 - Funding Information:
(retention time relative to cholesterol) 3.63, MS ( d z ) 515 (M+, 47%), 500 (18%), 486 (5%), 485 (58%), 482 (13%), 443 (32%), 442 (100%) 440 (21%), 428 (6%). The NMR chemical shifts (with assignment) for 3 are reported in Tables 1 and 2; m.p. 122-124OC, ; IR v C-N (not detected), 2957, 2924, 2854, 1460 (OMe), 1376 cm-1. Acknowledgements.W e thank the support of the Welch Foundation.
PY - 1995/9/1
Y1 - 1995/9/1
N2 - A facile preparation of the first bisubstrata analog 4,4- dimethyl 14a-methyl 24(R, S)-OMe, 25-dimethyl amino cholest-8-en-3β-o1 3 designed to interfere with the binding of (S)-adenosyl-L-methionine and of the natural sterol substrate to the (S)-adenosyl-L-methionine: Δ24(25)-sterol methyl transferase is reported here. Confirmation of the identity of the novel side chain modified N-sterol was obtained by 1H- and 13C-NMR.
AB - A facile preparation of the first bisubstrata analog 4,4- dimethyl 14a-methyl 24(R, S)-OMe, 25-dimethyl amino cholest-8-en-3β-o1 3 designed to interfere with the binding of (S)-adenosyl-L-methionine and of the natural sterol substrate to the (S)-adenosyl-L-methionine: Δ24(25)-sterol methyl transferase is reported here. Confirmation of the identity of the novel side chain modified N-sterol was obtained by 1H- and 13C-NMR.
UR - http://www.scopus.com/inward/record.url?scp=0029115345&partnerID=8YFLogxK
U2 - 10.1080/00397919508011808
DO - 10.1080/00397919508011808
M3 - Article
AN - SCOPUS:0029115345
VL - 25
SP - 2623
EP - 2630
JO - Synthetic Communications
JF - Synthetic Communications
SN - 0039-7911
IS - 17
ER -