Synthesis of a rationally designed inhibitor of the (s)-adenosyl-l-methionine: Δ24(25)-sterol methyl transferase

De an Guo, W. David Nes

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A facile preparation of the first bisubstrata analog 4,4- dimethyl 14a-methyl 24(R, S)-OMe, 25-dimethyl amino cholest-8-en-3β-o1 3 designed to interfere with the binding of (S)-adenosyl-L-methionine and of the natural sterol substrate to the (S)-adenosyl-L-methionine: Δ24(25)-sterol methyl transferase is reported here. Confirmation of the identity of the novel side chain modified N-sterol was obtained by 1H- and 13C-NMR.

Original languageEnglish
Pages (from-to)2623-2630
Number of pages8
JournalSynthetic Communications
Volume25
Issue number17
DOIs
StatePublished - Sep 1 1995

Fingerprint Dive into the research topics of 'Synthesis of a rationally designed inhibitor of the (s)-adenosyl-l-methionine: Δ<sup>24(25)</sup>-sterol methyl transferase'. Together they form a unique fingerprint.

Cite this