Abstract
A palladium-catalyzed isocyanide insertion-cyclization using low-cost and readily accessible 2-haloanilines, 2-iodophenylethanones, and isocyanides for efficient synthesis of 3-iminoindol-2-amine and cyclic enaminone derivatives has been developed. The method features low-cost and readily accessible starting materials, reliable scalability, and bond-forming efficiency as well as simple one-pot operation, which makes this strategy highly attractive. A reasonable mechanism for forming 3-iminoindol-2-amine involved double isocyanide insertion/cyclization process is proposed.
Original language | English |
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Pages (from-to) | 5764-5770 |
Number of pages | 7 |
Journal | Journal of Organic Chemistry |
Volume | 80 |
Issue number | 11 |
DOIs | |
State | Published - Jun 5 2015 |