Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells

Haibo Ge, Veena Vasandani, Jacquelyn K. Huff, Kenneth L. Audus, Richard H. Himes, Anna Seelig, Gunda I. Georg

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-glycoprotein in bovine brain microvessel endothelial cells. The three compounds were essentially equivalent to paclitaxel in cytotoxicity against NCI/ADR-RES cells. They also appeared to interact with P-glycoprotein in the endothelial cells with the two 10-deacetoxy compounds having less interaction than paclitaxel and 7-deoxypaclitaxel.

Original languageEnglish
Pages (from-to)433-436
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number2
DOIs
StatePublished - Jan 15 2006

Keywords

  • 10-Deacetoxy-7-deoxypaclitaxel
  • 10-Deacetoxypaclitaxel
  • 7-Deoxypaclitaxel
  • Bovine brain microvessel endothelial cells
  • NCI/ADR-RES
  • P-glycoprotein interaction
  • Synthesis

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