Synthesis and characterization of covalent mimics of phosphatidylinositol-4,5-bisphosphate micelles

Sarah A. Webb, Nichole K. Stewart, Lewis J. Belcher, Yehia Mechref, John W. Tomaszewski, Guangxiang Wu, Milos V. Novotny, Martha G. Oakley

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

There is increasing evidence that multivalency plays an important role in protein-lipid recognition and membrane targeting in biological systems. We describe here the preparation and characterization of multivalent analogues of the signaling lipid phosphatidylinositol-4,5-bisphosphate (PIP2). Tetherable analogues of the PIP2 headgroup were appended to polyamidoamine dendrimers via a squarate linker to afford polymers displaying four or eight headgroup moieties. This class of molecules should provide a powerful tool for the study of protein-lipid interactions.

Original languageEnglish
Pages (from-to)1790-1793
Number of pages4
JournalBiomacromolecules
Volume8
Issue number6
DOIs
StatePublished - Jun 2007

Fingerprint Dive into the research topics of 'Synthesis and characterization of covalent mimics of phosphatidylinositol-4,5-bisphosphate micelles'. Together they form a unique fingerprint.

Cite this