This paper investigates a hierarchical optimization procedure for the optimum synthesis of a double-axle steering mechanism by considering the dynamic load of a vehicle which is seldom discussed in the previous literature. Firstly, a multi-body model of double-axle steering is presented by characterizing the detailed leaf spring effect. Accordingly, the influences of dynamic load including the motion interference of steering linkage resulted from the elastic deformation of leaf spring, and the effects of wheel slip angle and the position discrepancy of wheel speed rotation centers are explored systematically. And then, a hierarchical optimization method based on target cascading methodology is proposed to classify the design variables of double-axle steering mechanism into four levels. At last, a double-axle steering mechanism of a heavy-duty truck is utilized to demonstrate the validity of this method. The simulation results indicate that the hierarchical optimization procedure addressed in this paper is effective and robust.