TY - JOUR
T1 - Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity
AU - Gordon-Larsen, Penny
AU - French, John E.
AU - Moustaid-Moussa, Naima
AU - Voruganti, Venkata S.
AU - Mayer-Davis, Elizabeth J.
AU - Bizon, Christopher A.
AU - Cheng, Zhiyong
AU - Stewart, Delisha A.
AU - Easterbrook, John W.
AU - Shaikh, Saame Raza
N1 - Publisher Copyright:
© 2021 Oxford University Press. All rights reserved.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Obesity is routinely considered as a single disease state, which drives a "one-size-fits-all"approach to treatment.We recently convened the first annual University of North Carolina Interdisciplinary Nutrition Sciences Symposium to discuss the heterogeneity of obesity and the need for translational science to advance understanding of this heterogeneity. The symposium aimed to advance scientific rigor in translational studies from animal to human models with the goal of identifying underlying mechanisms and treatments. In this review, we discuss fundamental gaps in knowledge of the heterogeneity of obesity ranging from cellular to population perspectives. We also advocate approaches to overcoming limitations in the field. Examples include the use of contemporary mouse genetic reference populationmodels such as the Collaborative Cross and Diversity Outbred mice that effectively model human genetic diversity and the use of translational models that integrate-omics and computational approaches from preclinical to clinical models of obesity. Finally, we suggest best scientific practices to ensure strong rigor that will allow investigators to delineate the sources of heterogeneity in the populationwith obesity. Collectively,we propose that it is critical to think of obesity as a heterogeneous diseasewith complexmechanisms and etiologies, requiring unique prevention and treatment strategies tailored to the individual.
AB - Obesity is routinely considered as a single disease state, which drives a "one-size-fits-all"approach to treatment.We recently convened the first annual University of North Carolina Interdisciplinary Nutrition Sciences Symposium to discuss the heterogeneity of obesity and the need for translational science to advance understanding of this heterogeneity. The symposium aimed to advance scientific rigor in translational studies from animal to human models with the goal of identifying underlying mechanisms and treatments. In this review, we discuss fundamental gaps in knowledge of the heterogeneity of obesity ranging from cellular to population perspectives. We also advocate approaches to overcoming limitations in the field. Examples include the use of contemporary mouse genetic reference populationmodels such as the Collaborative Cross and Diversity Outbred mice that effectively model human genetic diversity and the use of translational models that integrate-omics and computational approaches from preclinical to clinical models of obesity. Finally, we suggest best scientific practices to ensure strong rigor that will allow investigators to delineate the sources of heterogeneity in the populationwith obesity. Collectively,we propose that it is critical to think of obesity as a heterogeneous diseasewith complexmechanisms and etiologies, requiring unique prevention and treatment strategies tailored to the individual.
KW - clinical
KW - heterogeneity
KW - human
KW - mouse
KW - nutrition
KW - obesities
KW - pre-clinical
KW - prevention
KW - symposium
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85103644704&partnerID=8YFLogxK
U2 - 10.1093/advances/nmab040
DO - 10.1093/advances/nmab040
M3 - Review article
C2 - 33885739
AN - SCOPUS:85103644704
VL - 12
SP - 2023
EP - 2034
JO - Advances in Nutrition
JF - Advances in Nutrition
SN - 2161-8313
IS - 5
ER -