Synergistic silver/scandium catalysis for divergent synthesis of skeletally diverse chromene derivatives

Shuai Liu, Ke Chen, Xin Chan Lan, Wen Juan Hao, Guigen Li, Shu Jiang Tu, Bo Jiang

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The combination of AgTFA and Sc(OTf)3 enables the bimetallic synergistic catalysis of β-alkynyl ketones and o-hydroxybenzyl alcohols, allowing divergent synthesis of three classes of skeletally diverse chromene derivatives with generally good yields and high diastereoselectivity through dehydroxylated bi- and tri-cyclization cascades. The selectivity of these cycloadditions was controlled by adjusting the catalyst loading and reaction temperatures. The mechanisms for forming these compounds were proposed.

Original languageEnglish
Pages (from-to)10692-10695
Number of pages4
JournalChemical Communications
Volume53
Issue number77
DOIs
StatePublished - 2017

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