Abstract
The combination of AgTFA and Sc(OTf)3 enables the bimetallic synergistic catalysis of β-alkynyl ketones and o-hydroxybenzyl alcohols, allowing divergent synthesis of three classes of skeletally diverse chromene derivatives with generally good yields and high diastereoselectivity through dehydroxylated bi- and tri-cyclization cascades. The selectivity of these cycloadditions was controlled by adjusting the catalyst loading and reaction temperatures. The mechanisms for forming these compounds were proposed.
| Original language | English |
|---|---|
| Pages (from-to) | 10692-10695 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 53 |
| Issue number | 77 |
| DOIs | |
| State | Published - 2017 |
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Liu, S., Chen, K., Lan, X. C., Hao, W. J., Li, G., Tu, S. J., & Jiang, B. (2017). Synergistic silver/scandium catalysis for divergent synthesis of skeletally diverse chromene derivatives. Chemical Communications, 53(77), 10692-10695. https://doi.org/10.1039/c7cc05563c