Synergistic Rhodium/Copper Catalysis: Synthesis of 1,3-Enynes and N-Aryl Enaminones

Nan Nan Wang, Lei Rong Huang, Wen Juan Hao, Tian Shu Zhang, Guigen Li, Shu Jiang Tu, Bo Jiang

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Synergistic rhodium/copper catalysis enables new three-component coupling reactions of terminal alkynes and α-diazoketones and/or arylamines, allowing dediazotized carbene C-H insertion for the synthesis of functionalized 1,3-enynes and N-aryl enaminones with high stereoselectivity. The synthetic utility of these transformations results in subsequent C-C or/and C-N bond-forming reactions to effectively build up functional molecules with potential significance.

Original languageEnglish
Pages (from-to)1298-1301
Number of pages4
JournalOrganic Letters
Issue number6
StatePublished - Mar 18 2016


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