Synergistic Rhodium/Copper Catalysis: Synthesis of 1,3-Enynes and N-Aryl Enaminones

Nan-Nan Wang, Lei-Rong Huang, Wen-Juan Hao, Tian-Shu Zhang, Guigen Li, Shu-Jiang Tu, Bo Jiang

Research output: Contribution to journalArticle


Synergistic rhodium/copper catalysis enables new three-component coupling reactions of terminal apes and alpha-diazoketones and/or arylamines, allowing dediazotized carbene C-H insertion for the synthesis of functionalized 1,3-enynes and N-aryl enaminones with high stereoselectivity. The synthetic utility of these transformations results in subsequent C-C or/and C-N bond-forming reactions to effectively build up functional molecules with potential significance.
Original languageEnglish
Pages (from-to)1298-1301
JournalOrganic Letters
StatePublished - Mar 2016


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