Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses

J. Song, R. P. Joshi, K. H. Schoenbach

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one example of a bio-process at the plasma membrane. Our study thus suggests that the use of repetitive high-intensity voltage pulses could open up possibilities for a host of synergistic bio-responses involving both thermal and electrically driven phenomena.

Original languageEnglish
Pages (from-to)713-718
Number of pages6
JournalMedical and Biological Engineering and Computing
Volume49
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • Bioelectric
  • Modeling
  • Nanosecond, high intensity
  • Thermal effect
  • Voltage pulse

Fingerprint Dive into the research topics of 'Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses'. Together they form a unique fingerprint.

Cite this