Cotton fabric was functionalized with nanoparticles vapor deposition (NVD) of Al2O3 followed by molecular vapor deposition (MVD) of (tridecafluoro-1,1,2,2, -tetrahydrooctyl)- trichlorosilane (FOTS). The nanoparticles deposition increased the surface roughness, leading to higher contact angles. The morphology of the treated surfaces was observed with scanning electron microscopy. Fourier-transform infrared (FT-IR) analysis of the functionalized surfaces showed the presence of peaks corresponding to C-F, CF2, Al-O, and O-Al-O. Dynamic water contact angles were measured in order to assess the hydrophobic properties of the functionalized surface. Dynamic contact angles higher than 150° were obtained for water. In addition, samples treated with nanoparticles and FOTS layer showed low hysteresis when measuring advancing and receding contact angles.