Sulfonyl radical-enabled 6-endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones

Rong Fu, Wen-Juan Hao, Ya-Nan Wu, Nan-Nan Wang, Shu-Jiang Tu, Guigen Li, Bo Jiang

Research output: Contribution to journalArticle

Abstract

A new sulfonyl radical-triggered 6-endo-trig cyclization of unactivated 1,5-enynes under catalytic oxidation conditions for flexible synthesis of unprecedented unsymmetrical diaryl sulfones was established. This transformation could also proceed smoothly using 2-arylalkynyl-1,1’-biphenyls, delivering new sulfonylated phenanthrenes. The synthetic utility of these transformations results in subsequent C-S and C-C bond-forming reactions to effectively build up functional sulfones with potential significance.
Original languageEnglish
Pages (from-to)1452-1456
JournalOrganic Chemistry Frontiers
StatePublished - 2016

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