Sulfonyl radical-enabled 6-endo-trig cyclization for regiospecific
synthesis of unsymmetrical diaryl sulfones

Rong Fu; Wen-Juan Hao; Ya-Nan Wu; Nan-Nan Wang; Shu-Jiang Tu; Guigen Li; Bo Jiang

Sulfonyl radical-enabled 6-endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones

Rong Fu, Wen-Juan Hao, Ya-Nan Wu, Nan-Nan Wang, Shu-Jiang Tu, Guigen Li, Bo Jiang

Chemistry and Biochemistry

Research output: Contribution to journal › Article

Abstract

A new sulfonyl radical-triggered 6-endo-trig cyclization of unactivated 1,5-enynes under catalytic oxidation conditions for flexible synthesis of unprecedented unsymmetrical diaryl sulfones was established. This transformation could also proceed smoothly using 2-arylalkynyl-1,1’-biphenyls, delivering new sulfonylated phenanthrenes. The synthetic utility of these transformations results in subsequent C-S and C-C bond-forming reactions to effectively build up functional sulfones with potential significance.

Original language	English
Pages (from-to)	1452-1456
Journal	Organic Chemistry Frontiers
State	Published - 2016

Cite this

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title = "Sulfonyl radical-enabled 6-endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones",

abstract = "A new sulfonyl radical-triggered 6-endo-trig cyclization of unactivated 1,5-enynes under catalytic oxidation conditions for flexible synthesis of unprecedented unsymmetrical diaryl sulfones was established. This transformation could also proceed smoothly using 2-arylalkynyl-1,1{\textquoteright}-biphenyls, delivering new sulfonylated phenanthrenes. The synthetic utility of these transformations results in subsequent C-S and C-C bond-forming reactions to effectively build up functional sulfones with potential significance.",

author = "Rong Fu and Wen-Juan Hao and Ya-Nan Wu and Nan-Nan Wang and Shu-Jiang Tu and Guigen Li and Bo Jiang",

year = "2016",

language = "English",

pages = "1452--1456",

journal = "Organic Chemistry Frontiers",

issn = "2052-4110",

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TY - JOUR

T1 - Sulfonyl radical-enabled 6-endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones

AU - Fu, Rong

AU - Hao, Wen-Juan

AU - Wu, Ya-Nan

AU - Wang, Nan-Nan

AU - Tu, Shu-Jiang

AU - Li, Guigen

AU - Jiang, Bo

PY - 2016

Y1 - 2016

N2 - A new sulfonyl radical-triggered 6-endo-trig cyclization of unactivated 1,5-enynes under catalytic oxidation conditions for flexible synthesis of unprecedented unsymmetrical diaryl sulfones was established. This transformation could also proceed smoothly using 2-arylalkynyl-1,1’-biphenyls, delivering new sulfonylated phenanthrenes. The synthetic utility of these transformations results in subsequent C-S and C-C bond-forming reactions to effectively build up functional sulfones with potential significance.

AB - A new sulfonyl radical-triggered 6-endo-trig cyclization of unactivated 1,5-enynes under catalytic oxidation conditions for flexible synthesis of unprecedented unsymmetrical diaryl sulfones was established. This transformation could also proceed smoothly using 2-arylalkynyl-1,1’-biphenyls, delivering new sulfonylated phenanthrenes. The synthetic utility of these transformations results in subsequent C-S and C-C bond-forming reactions to effectively build up functional sulfones with potential significance.

M3 - Article

SP - 1452

EP - 1456

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

SN - 2052-4110

ER -

Sulfonyl radical-enabled 6-endo-trig cyclization for regiospecific synthesis of unsymmetrical diaryl sulfones

Abstract

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