Structure-antioxidant and anti-tumor activity of Teucrium polium phytochemicals

Wael A. Elmasri, Mohamed Elamir F. Hegazy, Yehia Mechref, Paul W. Paré

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Chemical characterization as well as antioxidant and anti-tumor activity are reported for isolated metabolites from Teucrium polium L. (Lamiaceae). Structures were identified using standard MS and NMR spectroscopic methods. Sesquiterpene absolute stereochemistry was determined based on a modified Mosher's reaction. Biological activity was evaluated by a cupric reducing antioxidant capacity (CUPRAC) assay and select compounds screened for anti-tumor activity. (1R,4S,10R) 10,11-dimethyl-dicyclohex-5(6)-en-1,4-diol-7-one and (R)-mandelonitrile-β-laminaribioside, together with ten previously reported compounds were identified. Antioxidant versus tumor-inhibition relationships was examined.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalPhytochemistry Letters
Volume15
DOIs
StatePublished - Mar 2016

Keywords

  • Anti-tumor activity
  • Antioxidant activity
  • Lamiacae
  • Mosher' reaction
  • Sesquiterpenes
  • Teucrium polium

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