Structural investigations of glycoconjugates at high sensitivity

Yehia Mechref, Milos V. Novotny

Research output: Contribution to journalArticle

277 Scopus citations

Abstract

Currently, deep structural insight to understand the rapidly advancing discoveries of new and varied functions of glycoconjugates in biological systems is often missing. Thus, the recent advances in oligosaccharide synthesis and the means to intercept carbohydrate biosynthetic pathways provide considerable rationale for an accelerated development of new therapeutics and vaccines based on sugar-sugar and sugar-lectin interactions. Simultaneously, the field is now being rapidly transformed through the availability of new structural tools and analytical methodologies.

Original languageEnglish
Pages (from-to)321-369
Number of pages49
JournalChemical Reviews
Volume102
Issue number2
DOIs
StatePublished - Feb 2002

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