High pressure Raman spectra and in situ electrical conductivity measurement of scheelite-structure PbMoO4 have been conducted using a diamond anvil cell (DAC). The Raman spectra of powdered PbMoO4 were determined up to 26.5GPa under nonhydrostatic conditions. The results indicate that PbMoO4 undergoes a transition from crystal to amorphous phase with increasing pressure, and the phase-transition pressure was about 12.5GPa. The electrical conductivity of PbMoO4 as a function of pressure and temperature was studied using a designed DAC. The experimental results show that the electrical conductivity of PbMoO4 increases with increasing pressure and temperature. Compared with the electrical conductivity value of PbMoO4 at 7.4GPa and 430K, it increases by about two orders of magnitude at 26.5GPa and 430K.