Stachaegyptin A-C: Neo-clerodane diterpenes from Stachys aegyptiaca

M. E.F. Hegazy, Ahmed R. Hamed, El Sayeda El-Kashoury, Alaa M. Shaheen, Wafaa A. Tawfik, Paul Pare, Essam Abdel-Sattar

Research output: Contribution to journalArticlepeer-review


© 2017 Phytochemical Society of Europe Phytochemical investigation of Stachys aegyptiaca resulted in the characterization of three new diterpenes (1-3) together with eleven known compounds including four neo-clerodane diterpenes and seven flavonoid aglycones. Structure elucidation was performed by spectroscopic analysis by HRFABMS, 1D and 2D NMR and X-ray. Isolated compounds were screened for anti-inflammatory activity using a lipopolysaccharide-induced nitric oxide inhibition assay employing murine macrophage cells. Among the assayed compounds, 13 (calycopterin) showed a concentration-dependent inhibition of LPS-induced nitric oxide release with a IC 50 of 62.5 μM.
Original languageEnglish
Pages (from-to)151-156
JournalPhytochemistry Letters
StatePublished - Sep 1 2017


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