Stachaegyptin A-C: Neo-clerodane diterpenes from Stachys aegyptiaca

M. E.F. Hegazy, Ahmed R. Hamed, El Sayeda A. El-Kashoury, Alaa M. Shaheen, Wafaa A. Tawfik, Paul W. Paré, Essam Abdel-Sattar

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Phytochemical investigation of Stachys aegyptiaca resulted in the characterization of three new diterpenes (1-3) together with eleven known compounds including four neo-clerodane diterpenes and seven flavonoid aglycones. Structure elucidation was performed by spectroscopic analysis by HRFABMS, 1D and 2D NMR and X-ray. Isolated compounds were screened for anti-inflammatory activity using a lipopolysaccharide-induced nitric oxide inhibition assay employing murine macrophage cells. Among the assayed compounds, 13 (calycopterin) showed a concentration-dependent inhibition of LPS-induced nitric oxide release with a IC50 of 62.5 μM.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalPhytochemistry Letters
StatePublished - Sep 2017


  • Anti-inflammatory activity
  • Diterpenes
  • Flavonoids
  • Lamiaceae
  • Stachys aegyptiaca

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