TY - JOUR
T1 - Spatial task-related brain activity and its association with preferred and fast pace gait speed in older adults
AU - Gonzales, Joaquin U.
AU - Al-Khalil, Kareem
AU - O'Boyle, Michael
N1 - Funding Information:
This work was supported by an American Heart Association Beginning Grant-in-Aid , United States (award number 15BGIA22710012). We would also like to thank Barbara Bowley and Kasey Rieken at the TTU Texas Tech Neuroimaging Institute for their assistance with MRI scanning.
Funding Information:
This work was supported by an American Heart Association Beginning Grant-in-Aid, United States (award number 15BGIA22710012). We would also like to thank Barbara Bowley and Kasey Rieken at the TTU Texas Tech Neuroimaging Institute for their assistance with MRI scanning.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/11/20
Y1 - 2019/11/20
N2 - Task-related brain activity is associated with preferred pace gait speed in older adults. Whether similar regional brain activity relates to fast pace gait speed has yet to be determined, but may provide insight into neural substrate important for walking under various conditions. This study measured regional blood-oxygen-level dependent (BOLD) changes using functional magnetic resonance imaging (fMRI) in response to a spatial Simon/Stroop task in community-dwelling older adults (N = 20, 63–80y). Preferred pace, fast pace, and dual-task gait speeds (picking up objects at preferred pace; fast walking over obstacles) were measured across a 7-meter course. Time to complete a fast pace 400 m walk test was also recorded. Partial correlations were used for all analyses after adjusting for age. Accuracy on incongruent trials of the spatial task was positively correlated with all fast walking conditions (all p < 0.01), but not preferred pace walking conditions. BOLD signal change in the left middle frontal gyrus during the spatial task was associated with preferred pace gait speed (r = 0.51, p = 0.02) and fast walking over obstacles (r = 0.53, p = 0.01). Interestingly, BOLD signal change in the bilateral precuneus was associated with fast pace gait speed (r = 0.58, p < 0.01), fast walking over obstacles (r = 0.48, p = 0.03), and 400 m walk time (r=−0.49, p = 0.02). These results find preferred and fast pace gait speed are associated with different regional task-related brain activity, with activation in the precuneus related with greater performance during fast pace walking.
AB - Task-related brain activity is associated with preferred pace gait speed in older adults. Whether similar regional brain activity relates to fast pace gait speed has yet to be determined, but may provide insight into neural substrate important for walking under various conditions. This study measured regional blood-oxygen-level dependent (BOLD) changes using functional magnetic resonance imaging (fMRI) in response to a spatial Simon/Stroop task in community-dwelling older adults (N = 20, 63–80y). Preferred pace, fast pace, and dual-task gait speeds (picking up objects at preferred pace; fast walking over obstacles) were measured across a 7-meter course. Time to complete a fast pace 400 m walk test was also recorded. Partial correlations were used for all analyses after adjusting for age. Accuracy on incongruent trials of the spatial task was positively correlated with all fast walking conditions (all p < 0.01), but not preferred pace walking conditions. BOLD signal change in the left middle frontal gyrus during the spatial task was associated with preferred pace gait speed (r = 0.51, p = 0.02) and fast walking over obstacles (r = 0.53, p = 0.01). Interestingly, BOLD signal change in the bilateral precuneus was associated with fast pace gait speed (r = 0.58, p < 0.01), fast walking over obstacles (r = 0.48, p = 0.03), and 400 m walk time (r=−0.49, p = 0.02). These results find preferred and fast pace gait speed are associated with different regional task-related brain activity, with activation in the precuneus related with greater performance during fast pace walking.
KW - Aging
KW - BOLD
KW - Functional MRI
KW - Gait speed
KW - Middle frontal gyrus
KW - Precuneus
UR - http://www.scopus.com/inward/record.url?scp=85072838756&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2019.134526
DO - 10.1016/j.neulet.2019.134526
M3 - Article
C2 - 31585208
AN - SCOPUS:85072838756
VL - 713
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
M1 - 134526
ER -