TY - JOUR
T1 - Somatostatin signaling and the regulation of growth and metabolism in fish
AU - Klein, Sarah E.
AU - Sheridan, Mark A.
N1 - Funding Information:
We thank Jeff Kittilson and Chad Wallock for their assistance with the preparation of this paper. Some of the research present in this paper was supported by grants from the National Science Foundation (IOB 0444860, EPS 0132289) to M.A.S.
PY - 2008/5/14
Y1 - 2008/5/14
N2 - The study of the somatostatins (SS) signaling system in fish has provided important information about the structure, function, and evolution of SSs and their receptors. The SS signaling system elicits widespread biological actions via multiple hormone variants, numerous receptor subtypes, and a variety of signal transduction pathways. SSs alter growth via both direct and indirect actions, including inhibiting growth hormone release at the pituitary, decreasing hepatic GH sensitivity, and lowering plasma IGF-I levels. Metabolism also is significantly influenced by SSs. SSs stimulate the breakdown of energy stores and influences digestion, food intake, nutrient absorption, and food conversion both directly and through the modulation of other hormonal systems. The study of fish, which display a diversity of habitat types and life history forms, reveals that the SS signaling system helps regulate energy partitioning and integrate metabolism with growth and other biological processes.
AB - The study of the somatostatins (SS) signaling system in fish has provided important information about the structure, function, and evolution of SSs and their receptors. The SS signaling system elicits widespread biological actions via multiple hormone variants, numerous receptor subtypes, and a variety of signal transduction pathways. SSs alter growth via both direct and indirect actions, including inhibiting growth hormone release at the pituitary, decreasing hepatic GH sensitivity, and lowering plasma IGF-I levels. Metabolism also is significantly influenced by SSs. SSs stimulate the breakdown of energy stores and influences digestion, food intake, nutrient absorption, and food conversion both directly and through the modulation of other hormonal systems. The study of fish, which display a diversity of habitat types and life history forms, reveals that the SS signaling system helps regulate energy partitioning and integrate metabolism with growth and other biological processes.
KW - Feeding
KW - Glycogenolysis
KW - Lipolysis
KW - Preprosomatostatin
KW - Somatostatin receptors
UR - http://www.scopus.com/inward/record.url?scp=43549092388&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2007.08.010
DO - 10.1016/j.mce.2007.08.010
M3 - Article
C2 - 17919810
AN - SCOPUS:43549092388
SN - 0303-7207
VL - 286
SP - 148
EP - 154
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -