Somatostatin inhibits insulin-like growth factor-I receptor expression in the gill of a teleost fish (Oncorhynchus mykiss)

Nicole M. Very, Mark A. Sheridan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Rainbow trout gill tissue was used to examine the role of somatostatin (SS) on insulin-like growth factor-I (IGF-I) receptor expression. In vivo implantation of fish with somatostatin-14 (SS-14) reduced expression of IGF-I receptor mRNAs as well as [125I]-IGF-I binding. In vitro incubation of gill filaments with SS-14 or various SS isoforms, including SS-28 and [Tyr7, Gly10]-SS-14-containing peptides, directly inhibited IGF-I receptor mRNA expression. SS-14 also inhibited [125I]-IGF-I binding in vitro. These data indicate that SSs inhibit the mRNA and functional expression of IGF-I receptors in gill, and suggest that SSs regulate growth in an extrapituitary manner by reducing sensitivity to IGF-I.

Original languageEnglish
Pages (from-to)4773-4777
Number of pages5
JournalFEBS Letters
Volume581
Issue number24
DOIs
StatePublished - Oct 2 2007

Keywords

  • Gene expression
  • Insulin-like growth factor-I
  • Insulin-like growth factor-I receptors
  • Rainbow trout model system
  • Somatostatin

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