Somatostatin inhibits insulin-like growth factor-I receptor expression in the gill of a teleost fish (Oncorhynchus mykiss)

Nicole M. Very; Mark A. Sheridan

doi:10.1016/j.febslet.2007.08.079

Somatostatin inhibits insulin-like growth factor-I receptor expression in the gill of a teleost fish (Oncorhynchus mykiss)

Nicole M. Very, Mark A. Sheridan

Graduate School

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Rainbow trout gill tissue was used to examine the role of somatostatin (SS) on insulin-like growth factor-I (IGF-I) receptor expression. In vivo implantation of fish with somatostatin-14 (SS-14) reduced expression of IGF-I receptor mRNAs as well as [¹²⁵I]-IGF-I binding. In vitro incubation of gill filaments with SS-14 or various SS isoforms, including SS-28 and [Tyr⁷, Gly¹⁰]-SS-14-containing peptides, directly inhibited IGF-I receptor mRNA expression. SS-14 also inhibited [¹²⁵I]-IGF-I binding in vitro. These data indicate that SSs inhibit the mRNA and functional expression of IGF-I receptors in gill, and suggest that SSs regulate growth in an extrapituitary manner by reducing sensitivity to IGF-I.

Original language	English
Pages (from-to)	4773-4777
Number of pages	5
Journal	FEBS Letters
Volume	581
Issue number	24
DOIs	https://doi.org/10.1016/j.febslet.2007.08.079
State	Published - Oct 2 2007

Keywords

Gene expression
Insulin-like growth factor-I
Insulin-like growth factor-I receptors
Rainbow trout model system
Somatostatin

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10.1016/j.febslet.2007.08.079

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title = "Somatostatin inhibits insulin-like growth factor-I receptor expression in the gill of a teleost fish (Oncorhynchus mykiss)",

abstract = "Rainbow trout gill tissue was used to examine the role of somatostatin (SS) on insulin-like growth factor-I (IGF-I) receptor expression. In vivo implantation of fish with somatostatin-14 (SS-14) reduced expression of IGF-I receptor mRNAs as well as [125I]-IGF-I binding. In vitro incubation of gill filaments with SS-14 or various SS isoforms, including SS-28 and [Tyr7, Gly10]-SS-14-containing peptides, directly inhibited IGF-I receptor mRNA expression. SS-14 also inhibited [125I]-IGF-I binding in vitro. These data indicate that SSs inhibit the mRNA and functional expression of IGF-I receptors in gill, and suggest that SSs regulate growth in an extrapituitary manner by reducing sensitivity to IGF-I.",

keywords = "Gene expression, Insulin-like growth factor-I, Insulin-like growth factor-I receptors, Rainbow trout model system, Somatostatin",

author = "Very, {Nicole M.} and Sheridan, {Mark A.}",

note = "Funding Information: We thank Leslie Alexander, Whitney Fleck, Jun-Yang Gong, Jeffrey Kittilson, Sarah Klein, Felicia Lamb, Lindsey Norbeck, Jayson Poppinga, Chad Walock, and Nathan Weiderholt for their assistance in conducting these studies and in preparing the manuscript. This research was supported by Grants from the National Science Foundation, USA (IOB 0444860, EPS 0132289) to M.A.S. N.M.V. was supported by a fellowship from the North Dakota Experimental Program to Stimulate Competitive Research. ",

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AB - Rainbow trout gill tissue was used to examine the role of somatostatin (SS) on insulin-like growth factor-I (IGF-I) receptor expression. In vivo implantation of fish with somatostatin-14 (SS-14) reduced expression of IGF-I receptor mRNAs as well as [125I]-IGF-I binding. In vitro incubation of gill filaments with SS-14 or various SS isoforms, including SS-28 and [Tyr7, Gly10]-SS-14-containing peptides, directly inhibited IGF-I receptor mRNA expression. SS-14 also inhibited [125I]-IGF-I binding in vitro. These data indicate that SSs inhibit the mRNA and functional expression of IGF-I receptors in gill, and suggest that SSs regulate growth in an extrapituitary manner by reducing sensitivity to IGF-I.

KW - Gene expression

KW - Insulin-like growth factor-I

KW - Insulin-like growth factor-I receptors

KW - Rainbow trout model system

KW - Somatostatin

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ER -

Somatostatin inhibits insulin-like growth factor-I receptor expression in the gill of a teleost fish (Oncorhynchus mykiss)

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