Somatostatin inhibits growth of rainbow trout

N. M. Very, D. Knutson, J. D. Kittilson, M. A. Sheridan

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38 Scopus citations


Implantation of rainbow trout Oncorhynchus mykiss with somatostatin-14 (SS-14) for 20 days resulted in reduced food conversion as well as significant growth retardation compared to controls. Relative growth as mass was reduced by 20%, whereas relative growth by length was reduced by 45%. A single intraperitoneal injection of SS-14 reduced plasma levels of growth hormone (GH), insulin-like growth factor-I (IGF-I) and insulin. SS-14 injection also reduced [35S]-sulphate incorporation into gill cartilage compared to saline-injected fish. In addition, in vitro incubation of gill cartilage with SS-14 reduced [35S]-sulphate incorporation in a dose-related manner. These results indicate that SS-14 inhibits growth of rainbow trout and suggests that SS-14, in addition to influencing GH, may play an extra-pituitary role in the modulation of the GH-IGF-I axis.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalJournal of Fish Biology
Issue number1
StatePublished - 2001


  • Growth hormone
  • Insulin-like growth factor-I
  • Somatostatin
  • [S]-sulphate incorporation


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