TY - JOUR
T1 - Somatostatin inhibits growth of rainbow trout
AU - Very, N. M.
AU - Knutson, D.
AU - Kittilson, J. D.
AU - Sheridan, M. A.
PY - 2001
Y1 - 2001
N2 - Implantation of rainbow trout Oncorhynchus mykiss with somatostatin-14 (SS-14) for 20 days resulted in reduced food conversion as well as significant growth retardation compared to controls. Relative growth as mass was reduced by 20%, whereas relative growth by length was reduced by 45%. A single intraperitoneal injection of SS-14 reduced plasma levels of growth hormone (GH), insulin-like growth factor-I (IGF-I) and insulin. SS-14 injection also reduced [35S]-sulphate incorporation into gill cartilage compared to saline-injected fish. In addition, in vitro incubation of gill cartilage with SS-14 reduced [35S]-sulphate incorporation in a dose-related manner. These results indicate that SS-14 inhibits growth of rainbow trout and suggests that SS-14, in addition to influencing GH, may play an extra-pituitary role in the modulation of the GH-IGF-I axis.
AB - Implantation of rainbow trout Oncorhynchus mykiss with somatostatin-14 (SS-14) for 20 days resulted in reduced food conversion as well as significant growth retardation compared to controls. Relative growth as mass was reduced by 20%, whereas relative growth by length was reduced by 45%. A single intraperitoneal injection of SS-14 reduced plasma levels of growth hormone (GH), insulin-like growth factor-I (IGF-I) and insulin. SS-14 injection also reduced [35S]-sulphate incorporation into gill cartilage compared to saline-injected fish. In addition, in vitro incubation of gill cartilage with SS-14 reduced [35S]-sulphate incorporation in a dose-related manner. These results indicate that SS-14 inhibits growth of rainbow trout and suggests that SS-14, in addition to influencing GH, may play an extra-pituitary role in the modulation of the GH-IGF-I axis.
KW - Growth hormone
KW - Insulin-like growth factor-I
KW - Somatostatin
KW - [S]-sulphate incorporation
UR - http://www.scopus.com/inward/record.url?scp=0034919783&partnerID=8YFLogxK
U2 - 10.1006/jfbi.2001.1632
DO - 10.1006/jfbi.2001.1632
M3 - Article
AN - SCOPUS:0034919783
VL - 59
SP - 157
EP - 165
JO - Journal of Fish Biology
JF - Journal of Fish Biology
SN - 0022-1112
IS - 1
ER -