TY - JOUR
T1 - Somatostatin and somatostatin receptors in fish growth
AU - Sheridan, Mark A.
AU - Hagemeister, Alison L.
N1 - Funding Information:
We thank Jeff Kittilson for his assistance with the preparation of this paper. Some of the research presented in this paper was supported by a grant from the National Science Foundation ( IOS 0920116 ) to M.A.S.
PY - 2010/7
Y1 - 2010/7
N2 - Multiple forms of somatostatin (SS) and SS receptors (SSTR) are produced widely in the tissues of fish and interact to coordinate numerous physiological processes. Insight into their role in growth regulation emerged from studies of abnormal growth and of whole animals. The influence of SS on organismal growth operates at several levels of the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) system. SS inhibits production and release of pituitary GH, but not all forms of SS are equipotent in this action. SS also influences the GH-IGF-1 system in an extrapituitary manner by reducing sensitivity to GH as well as by inhibiting IGF-1 production and secretion, and diminishing IGF-1 sensitivity. Peripheral actions of SS are important for the local control of growth and may help to coordinate growth with other processes such as metabolism, development, and reproduction by reprogramming cell responsiveness.
AB - Multiple forms of somatostatin (SS) and SS receptors (SSTR) are produced widely in the tissues of fish and interact to coordinate numerous physiological processes. Insight into their role in growth regulation emerged from studies of abnormal growth and of whole animals. The influence of SS on organismal growth operates at several levels of the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) system. SS inhibits production and release of pituitary GH, but not all forms of SS are equipotent in this action. SS also influences the GH-IGF-1 system in an extrapituitary manner by reducing sensitivity to GH as well as by inhibiting IGF-1 production and secretion, and diminishing IGF-1 sensitivity. Peripheral actions of SS are important for the local control of growth and may help to coordinate growth with other processes such as metabolism, development, and reproduction by reprogramming cell responsiveness.
KW - Growth hormone receptors
KW - Growth hormone secretion
KW - Growth regulation
KW - Insulin-like growth factor receptors
KW - Insulin-like growth factor-1
KW - Somatostatin
KW - Somatostatin receptors
UR - http://www.scopus.com/inward/record.url?scp=77953356318&partnerID=8YFLogxK
U2 - 10.1016/j.ygcen.2009.09.002
DO - 10.1016/j.ygcen.2009.09.002
M3 - Article
C2 - 19735661
AN - SCOPUS:77953356318
SN - 0016-6480
VL - 167
SP - 360
EP - 365
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
IS - 3
ER -