Solution-phase-peptide synthesis via the group-assisted purification (GAP) chemistry without using chromatography and recrystallization

Jianbin Wu, Guanghui An, Siqi Lin, Jianbo Xie, Wei Zhou, Hao Sun, Yi Pan, Guigen Li

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The solution phase synthesis of N-protected amino acids and peptides has been achieved through the Group-Assisted Purification (GAP) chemistry by avoiding disadvantages of other methods in regard to the difficult scale-up, expenses of solid and soluble polymers, etc. The GAP synthesis can reduce the use of solvents, silica gels, energy and manpower. In addition, the GAP auxiliary can be conveniently recovered for re-use and is environmentally friendly and benign, and substantially reduces waste production in academic labs and industry.

Original languageEnglish
Pages (from-to)1259-1261
Number of pages3
JournalChemical Communications
Volume50
Issue number10
DOIs
StatePublished - Jan 2 2014

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