Social determinants and the classification of disease: descriptive epidemiology of selected socially mediated disease constellations.

R S Levine, B A Kilbourne, G G Rust, M A Langston, B A Husaini, LisaAnn Gittner, Charlie H Hennekens

Research output: Other contributionpeer-review

Abstract

Background Most major diseases have important social determinants. In this context, classification of disease based on etiologic or anatomic criteria may be neither mutually exclusive nor optimal. Methods and Findings Units of analysis comprised large metropolitan central and fringe metropolitan counties with reliable mortality rates – (n = 416). Participants included infants and adults ages 25 to 64 years with selected causes of death (1999 to 2006). Exposures included that residential segregation and race-specific social deprivation variables. Main outcome measures were obtained via principal components analyses with an orthogonal rotation to identify a common factor. To discern whether the common factor was socially mediated, negative binomial multiple regression models were developed for which the dependent variable was the common factor. Results showed that infant deaths, mortality from assault, and malignant neoplasm of the trachea, bronchus and lung formed a common factor for
Original languageEnglish
PublisherPlosOne
Volume9
StatePublished - Aug 2014

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