Simulations of distributed voltages in full-body biomodels using symmetric factorization with massively parallel solvers in response to external pulsing

An improved model of our previous work is presented to compute spatial electric potentials in whole body biomodels. This is a distributed modeling scheme that employs symmetric factorization to decrease the memory requirement, reduce run-time overhead, and facilitate analyses of significantly larger biomodels. Such improved full-body modeling will help in the study of bioresponses to electrical stimuli in a more accurate, realistic, and comprehensive manner. For example, the voltages at various sites and tissue locations could be evaluated to probe the role of nanosecond high-intensity pulsed electric fields in blocking neural action potential propagation. Here, it is shown in rat and monkey biomodels that tissue and/or cell functionality at the spinal and thoracic regions is most likely to be affected in keeping with some recent experiments.