Simulations of distributed voltages in full-body biomodels using symmetric factorization with massively parallel solvers in response to external pulsing

Ashutosh Mishra, Ravindra P. Joshi

Research output: Contribution to journalArticle

Abstract

An improved model of our previous work is presented to compute spatial electric potentials in whole body biomodels. This is a distributed modeling scheme that employs symmetric factorization to decrease the memory requirement, reduce run-time overhead, and facilitate analyses of significantly larger biomodels. Such improved full-body modeling will help in the study of bioresponses to electrical stimuli in a more accurate, realistic, and comprehensive manner. For example, the voltages at various sites and tissue locations could be evaluated to probe the role of nanosecond high-intensity pulsed electric fields in blocking neural action potential propagation. Here, it is shown in rat and monkey biomodels that tissue and/or cell functionality at the spinal and thoracic regions is most likely to be affected in keeping with some recent experiments.

Original languageEnglish
Pages (from-to)1673-1679
Number of pages7
JournalIEEE Transactions on Plasma Science
Volume36
Issue number4 PART 3
DOIs
StatePublished - Aug 2008

Keywords

  • Bioelectrics
  • Cholesky factorization
  • Full-body modeling
  • Parallel computation
  • Simulation

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