Simulation studies of ultrashort, high-intensity electric pulse induced action potential block in whole-animal nerves

Ravindra P. Joshi; Ashutosh Mishra; Jiahui Song; Andrei G. Pakhomov; Karl H. Schoenbach

doi:10.1109/TBME.2007.912424

Simulation studies of ultrashort, high-intensity electric pulse induced action potential block in whole-animal nerves

Ravindra P. Joshi, Ashutosh Mishra, Jiahui Song, Andrei G. Pakhomov, Karl H. Schoenbach

Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A theoretical study of possible neuromuscular incapacitation based on the application of high-intensity, ultrashort electric pulses is presented. The analysis is applied to a rat, but the approach is general and can be extended to any whole-animal and applies for any arbitrary pulse waveform. It is hypothesized that repeatable and reversible action potential blocks in nerves can be attained based on the electroporation mechanism. Our numerical studies are based on the Hodgkin-Huxley distributed circuit representation of nerves, and incorporate a nodal analysis for the time-dependent and volumetric perturbing potentials and internal electric fields in whole animals. The predictions are compared to actual 600-ns experimental reports on rats and shown to be in very good agreement. Effective strength-duration plots for neuromuscular incapacitation are also generated.

Original language	English
Pages (from-to)	1391-1398
Number of pages	8
Journal	IEEE Transactions on Biomedical Engineering
Volume	55
Issue number	4
DOIs	https://doi.org/10.1109/TBME.2007.912424
State	Published - Apr 2008

Keywords

Action potential (AP) block
Electroporation
High-voltage pulse
Myelinated nerve simulation
Rat-model

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10.1109/TBME.2007.912424

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title = "Simulation studies of ultrashort, high-intensity electric pulse induced action potential block in whole-animal nerves",

abstract = "A theoretical study of possible neuromuscular incapacitation based on the application of high-intensity, ultrashort electric pulses is presented. The analysis is applied to a rat, but the approach is general and can be extended to any whole-animal and applies for any arbitrary pulse waveform. It is hypothesized that repeatable and reversible action potential blocks in nerves can be attained based on the electroporation mechanism. Our numerical studies are based on the Hodgkin-Huxley distributed circuit representation of nerves, and incorporate a nodal analysis for the time-dependent and volumetric perturbing potentials and internal electric fields in whole animals. The predictions are compared to actual 600-ns experimental reports on rats and shown to be in very good agreement. Effective strength-duration plots for neuromuscular incapacitation are also generated.",

keywords = "Action potential (AP) block, Electroporation, High-voltage pulse, Myelinated nerve simulation, Rat-model",

author = "Joshi, {Ravindra P.} and Ashutosh Mishra and Jiahui Song and Pakhomov, {Andrei G.} and Schoenbach, {Karl H.}",

note = "Funding Information: Manuscript received August 14 2007; revised September 28, 2007. This work was supported in part by an AFOSR-MURI grant on Subcellular Responses to Narrowband and Wideband Radio Frequency Radiation managed by Dr. R. J. Barker, and by the Office of Naval Research. Asterisk indicates corresponding author. *R. P. Joshi is with the Department of Electrical and Computer Engineering, K-231, Old Dominion University, Norfolk, VA 23529-0246 USA and also with the Frank Reidy Research Centre for Bioelectrics, Norfolk, VA 23510 USA (e-mail: rjoshi@odu.edu).",

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AU - Pakhomov, Andrei G.

AU - Schoenbach, Karl H.

N1 - Funding Information: Manuscript received August 14 2007; revised September 28, 2007. This work was supported in part by an AFOSR-MURI grant on Subcellular Responses to Narrowband and Wideband Radio Frequency Radiation managed by Dr. R. J. Barker, and by the Office of Naval Research. Asterisk indicates corresponding author. *R. P. Joshi is with the Department of Electrical and Computer Engineering, K-231, Old Dominion University, Norfolk, VA 23529-0246 USA and also with the Frank Reidy Research Centre for Bioelectrics, Norfolk, VA 23510 USA (e-mail: rjoshi@odu.edu).

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AB - A theoretical study of possible neuromuscular incapacitation based on the application of high-intensity, ultrashort electric pulses is presented. The analysis is applied to a rat, but the approach is general and can be extended to any whole-animal and applies for any arbitrary pulse waveform. It is hypothesized that repeatable and reversible action potential blocks in nerves can be attained based on the electroporation mechanism. Our numerical studies are based on the Hodgkin-Huxley distributed circuit representation of nerves, and incorporate a nodal analysis for the time-dependent and volumetric perturbing potentials and internal electric fields in whole animals. The predictions are compared to actual 600-ns experimental reports on rats and shown to be in very good agreement. Effective strength-duration plots for neuromuscular incapacitation are also generated.

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Simulation studies of ultrashort, high-intensity electric pulse induced action potential block in whole-animal nerves

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