Simulation of Poration by Shockwave Induced Multiple Nanobubble Collapse in Cell Membranes

Qin Hu, Lijuan Zhang, Ravindra Joshi

Research output: Contribution to journalArticlepeer-review

Abstract

Synergistic applications of electric field combined with nanojet-based mechanical pressure have recently been shown to help create larger pores and provide control of the aspect ratio in biological membranes. The nanojets are formed by the collapse of nanobubbles in the vicinity of biomembranes upon being subjected to external shockwaves. Here we analyze the effects produced by the collapse of multiple nanobubbles in the added presence of an electric field. Our simulations, based on molecular dynamics, show that not only would multiple nanobubbles make it possible to create larger pores, but also increase the pore density on the surface of biological cells. Both aspects could aid in the transport of drugs and genes for bio-medical applications.
Original languageEnglish
Pages (from-to)045006 9 pages
JournalAIP Advances
DOIs
StatePublished - Apr 15 2019

Fingerprint

Dive into the research topics of 'Simulation of Poration by Shockwave Induced Multiple Nanobubble Collapse in Cell Membranes'. Together they form a unique fingerprint.

Cite this