Silver-Mediated Radical C(sp3)-H Biphosphinylation and Nitration of β-Alkynyl Ketones for Accessing Functional Isochromenes

Jun Sun, Jiang Kai Qiu, Ya Nan Wu, Wen Juan Hao, Cheng Guo, Guigen Li, Shu Jiang Tu, Bo Jiang

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Silver-mediated C(sp3)-H functionalization and 6-endo-dig oxo-cyclization of conjugated β-alkynyl ketones have been established under oxidative conditions. The reaction leads to the concise formation of a wide range of isochromenes via C(sp3)-H bond-breaking and radical addition steps. Dual and monofunctional isochromene products were selectively controlled by using either electron-rich or electron-deficient radical sources.

Original languageEnglish
Pages (from-to)754-757
Number of pages4
JournalOrganic Letters
Volume19
Issue number4
DOIs
StatePublished - Feb 17 2017

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