Serum aminotransferase changes with significant weight loss: sex and age effects

A. Suzuki, Martin Binks, R. Sha, A. Wachholtz, H. Eisenson, A. M. Diehl

Research output: Contribution to journalArticlepeer-review


In obese subjects, the liver may be differentially affected by significant weight loss depending on as yet unknown factors. We explored clinical factors associated with serum alanine aminotransferase (ALT) changes during significant weight loss in a residential weight loss program. Clinical data from 362 adults who received a comprehensive weight loss intervention (ie, diets, physical fitness, and behavioral modification) in the program were analyzed. Serum ALT was used as a surrogate marker of liver injury. The ALT changes during the program were calculated to create study outcome categories (improvement, no change, or deterioration of ALT during significant weight loss). Variables of demography, lifestyle, and comorbidities at baseline, and total/rate of weight change during the program were explored for associations with the ALT change categories using multiple logistic regression models. Variation by sex was apparent among predictors of ALT deterioration; men with rapid weight los
Original languageEnglish
Pages (from-to)177-85
JournalMetabolism- Clinical and Experimental
StatePublished - 2010


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