Self-consistent simulations of electroporation dynamics in biological cells subjected to ultrashort electrical pulses

R. P. Joshi, Q. Hu, R. Aly, K. H. Schoenbach, H. P. Hjalmarson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A self-consistent model analysis of electroporation in biological cells was carried out based on the coupled Laplace-Nernst-Planck-Smoluchowski equations. The physical processes of pore generation, drift, and diffusion in r space were all comprehensively included. A pore-radius-dependent energy barrier to ionic transport accounted for cellular variations. As a result, predictions and qualitative understanding of the cellular response to short, high electric field pulses were obtained.

Original languageEnglish
Article number011913
Pages (from-to)1-10
Number of pages10
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume64
Issue number1
DOIs
StatePublished - Jul 2001

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