A self-consistent model analysis of electroporation in biological cells was carried out based on the coupled Laplace-Nernst-Planck-Smoluchowski equations. The physical processes of pore generation, drift, and diffusion in r space were all comprehensively included. A pore-radius-dependent energy barrier to ionic transport accounted for cellular variations. As a result, predictions and qualitative understanding of the cellular response to short, high electric field pulses were obtained.
|Number of pages||10|
|Journal||Physical Review E - Statistical, Nonlinear, and Soft Matter Physics|
|State||Published - Jul 2001|