Self-consistent simulations of electroporation dynamics in biological cells subjected to ultrashort electrical pulses

R. P. Joshi; Q. Hu; R. Aly; K. H. Schoenbach; H. P. Hjalmarson

doi:10.1103/PhysRevE.64.011913

Self-consistent simulations of electroporation dynamics in biological cells subjected to ultrashort electrical pulses

R. P. Joshi, Q. Hu, R. Aly, K. H. Schoenbach, H. P. Hjalmarson

Electrical and Computer Engineering

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9 Scopus citations

Abstract

A self-consistent model analysis of electroporation in biological cells was carried out based on the coupled Laplace-Nernst-Planck-Smoluchowski equations. The physical processes of pore generation, drift, and diffusion in r space were all comprehensively included. A pore-radius-dependent energy barrier to ionic transport accounted for cellular variations. As a result, predictions and qualitative understanding of the cellular response to short, high electric field pulses were obtained.

Original language	English
Article number	011913
Pages (from-to)	1-10
Number of pages	10
Journal	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume	64
Issue number	1
DOIs	https://doi.org/10.1103/PhysRevE.64.011913
State	Published - Jul 2001

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10.1103/PhysRevE.64.011913

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abstract = "A self-consistent model analysis of electroporation in biological cells was carried out based on the coupled Laplace-Nernst-Planck-Smoluchowski equations. The physical processes of pore generation, drift, and diffusion in r space were all comprehensively included. A pore-radius-dependent energy barrier to ionic transport accounted for cellular variations. As a result, predictions and qualitative understanding of the cellular response to short, high electric field pulses were obtained.",

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AU - Hjalmarson, H. P.

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Self-consistent simulations of electroporation dynamics in biological cells subjected to ultrashort electrical pulses

Abstract

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