Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing in Vivo

Steven A. Castleberry; Benjamin D. Almquist; Wei Li; Tiago Reis; John Chow; Sarah Mayner; Paula T. Hammond

doi:10.1002/adma.201503565

Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing in Vivo

Steven A. Castleberry, Benjamin D. Almquist, Wei Li, Tiago Reis, John Chow, Sarah Mayner, Paula T. Hammond

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed.

Original language	English
Pages (from-to)	1809-1817
Number of pages	9
Journal	Advanced Materials
Volume	28
Issue number	9
DOIs	https://doi.org/10.1002/adma.201503565
State	Published - Mar 2 2016

Keywords

controlled local delivery
diabetic wound healing
layer-by-layer
polymer coatings
siRNA delivery

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title = "Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing in Vivo",

abstract = "The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed.",

keywords = "controlled local delivery, diabetic wound healing, layer-by-layer, polymer coatings, siRNA delivery",

author = "Castleberry, {Steven A.} and Almquist, {Benjamin D.} and Wei Li and Tiago Reis and John Chow and Sarah Mayner and Hammond, {Paula T.}",

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AU - Castleberry, Steven A.

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AU - Li, Wei

AU - Reis, Tiago

AU - Chow, John

AU - Mayner, Sarah

AU - Hammond, Paula T.

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KW - controlled local delivery

KW - diabetic wound healing

KW - layer-by-layer

KW - polymer coatings

KW - siRNA delivery

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Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing in Vivo

Abstract

Keywords

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