Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing in Vivo

Steven A. Castleberry, Benjamin D. Almquist, Wei Li, Tiago Reis, John Chow, Sarah Mayner, Paula T. Hammond

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed.

Original languageEnglish
Pages (from-to)1809-1817
Number of pages9
JournalAdvanced Materials
Volume28
Issue number9
DOIs
StatePublished - Mar 2 2016

Keywords

  • controlled local delivery
  • diabetic wound healing
  • layer-by-layer
  • polymer coatings
  • siRNA delivery

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    Castleberry, S. A., Almquist, B. D., Li, W., Reis, T., Chow, J., Mayner, S., & Hammond, P. T. (2016). Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing in Vivo. Advanced Materials, 28(9), 1809-1817. https://doi.org/10.1002/adma.201503565