Selective aldol condensation or cyclotrimerization reactions catalyzed by FeCl<inf>3</inf>

Renzo Arias-Ugarte, Francis Wekesa, Michael Findlater

Research output: Contribution to journalArticlepeer-review


© 2015 Elsevier Ltd. The inexpensive and commercially available FeCl 3 catalyzes the selective homo-aldol condensation of aldehydes into the corresponding α-β unsaturated aldehydes, presumably through an unobserved aldol intermediate. Surprisingly the reaction course can be diverted to produce 1,3,5-trioxanes via aldehyde cyclotrimerization. Selectivity for trioxanes is achieved at lower temperatures and is enhanced by the presence of water, contrary to prior reports. A broad range of aliphatic and aromatic aldehydes are capable of undergoing these transformations; short reaction times, high yields, scalability, and easy purification processes are also described.
Original languageEnglish
Pages (from-to)2406-2411
JournalTetrahedron Letters
StatePublished - May 6 2015


Dive into the research topics of 'Selective aldol condensation or cyclotrimerization reactions catalyzed by FeCl<inf>3</inf>'. Together they form a unique fingerprint.

Cite this