Personnel are critical components of many systems. Properly considering human capability and the man-machine interface is essential in order to maximize system effectiveness. The overall performance of a system is often directly related to how system personnel are scheduled. This chapter summarizes research related to scheduling personnel where the objective is to optimize system performance while considering human performance limitations and personnel well-being. Topics such as work rest scheduling, job rotation, cross-training, and task learning and forgetting are considered. For these topics, mathematical models and best practices are described. Additionally, important topics for future research are identified and discussed.