TY - JOUR
T1 - Role of macrophage autophagy in atherosclerosis
T2 - Modulation by bioactive compounds
AU - Zahid, Khurshidul
AU - Sufian, Hazera Binte
AU - Choudhury, Mahua
AU - Yamasaki, Masao
AU - Al-Harrasi, Ahmed
AU - Moustaid-Moussa, Naima
AU - Rahman, Shaikh Mizanoor
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
PY - 2021/4
Y1 - 2021/4
N2 - Atherosclerosis is a chronic inflammatory disease associated with lipid metabolism disorder. Autophagy is a catabolic process and contributes to maintaining cellular homeostasis. Substantial evidence suggests that defective autophagy is implicated in several diseases, including atherosclerosis, while increased autophagy mitigates atherosclerosis development. Thus, understanding the mechanisms of autophagy regulation and its association with atherosclerosis is vital to develop new therapies against atherosclerosis. Dietary bioactive compounds are non-nutrient natural compounds that include phenolics, flavonoids, and carotenoids. Importantly, these bioactive compounds possess anti-inflammatory, antioxidant, and antibacterial properties that may alleviate various chronic diseases. Recently, examining the effects of bioactive compounds on autophagy activity in atherogenesis has drawn considerable attention. The current review discusses the role of macrophage autophagy in the development and progression of atherosclerosis. We also summarize our current knowledge of the therapeutic potential of bioactive compounds on atherosclerosis and autophagy.
AB - Atherosclerosis is a chronic inflammatory disease associated with lipid metabolism disorder. Autophagy is a catabolic process and contributes to maintaining cellular homeostasis. Substantial evidence suggests that defective autophagy is implicated in several diseases, including atherosclerosis, while increased autophagy mitigates atherosclerosis development. Thus, understanding the mechanisms of autophagy regulation and its association with atherosclerosis is vital to develop new therapies against atherosclerosis. Dietary bioactive compounds are non-nutrient natural compounds that include phenolics, flavonoids, and carotenoids. Importantly, these bioactive compounds possess anti-inflammatory, antioxidant, and antibacterial properties that may alleviate various chronic diseases. Recently, examining the effects of bioactive compounds on autophagy activity in atherogenesis has drawn considerable attention. The current review discusses the role of macrophage autophagy in the development and progression of atherosclerosis. We also summarize our current knowledge of the therapeutic potential of bioactive compounds on atherosclerosis and autophagy.
UR - http://www.scopus.com/inward/record.url?scp=85104824533&partnerID=8YFLogxK
U2 - 10.1042/BCJ20200894
DO - 10.1042/BCJ20200894
M3 - Review article
C2 - 33861844
AN - SCOPUS:85104824533
SN - 0264-6021
VL - 478
SP - 1359
EP - 1375
JO - Biochemical Journal
JF - Biochemical Journal
IS - 7
ER -