Role of electropores on membrane blebbing-A model energy-based analysis

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Cell blebbing has been observed invitro in the context of external intense electric field pulsing of biological cells. Here, we propose that this is promoted in part by the formation of electropores that influence the membrane tension. Model energy-based calculations of bleb formation are presented. It is shown that the high density of electropores (with radii around 1 nm) driven by a nanosecond voltage pulse could lead to quasi-stable 1 μm blebs, and that the preferred site for bleb formation would predominantly be near the polar caps facing the electrodes. This is in keeping with recent experimental reports. Our study has implications to pore closing and their lifetimes, an aspect important for intracellular drug delivery.

Original languageEnglish
Article number064703
JournalJournal of Applied Physics
Issue number6
StatePublished - Sep 15 2012


Dive into the research topics of 'Role of electropores on membrane blebbing-A model energy-based analysis'. Together they form a unique fingerprint.

Cite this