Robust approaches for genetic regulatory network modeling and intervention: A review of recent advances

Ranadip Pal, Sonal Bhattacharya, Mehmet Umut Caglar

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

There are two primary objectives for modeling of genetic regulatory networks (GRNs): 1) to better understand the gene interactions and relationships on a holistic level and predict the behavior of biological systems;and 2) to design and analyze control strategies for moving the state of a network from an undesirable location to a desirable one. The control can be for the purpose of systems medicine to move the GRN from a diseased state to a nondiseased state or for synthetic biology purposes to tune the parameters of a synthetic circuit to produce complex novel behaviors.

Original languageEnglish
Article number6105449
Pages (from-to)66-76
Number of pages11
JournalIEEE Signal Processing Magazine
Volume29
Issue number1
DOIs
StatePublished - Jan 2012

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