Rigorous control conditions diminish treatment effects in weight loss-randomized controlled trials

J. A. Dawson, K. A. Kaiser, O. Affuso, G. R. Cutter, D. B. Allison

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Background:It has not been established whether control conditions with large weight losses (WLs) diminish expected treatment effects in WL or prevention of weight gain (PWG)-randomized controlled trials (RCTs).Subjects/Methods:We performed a meta-analysis of 239 WL/PWG RCTs that include a control group and at least one treatment group. A maximum likelihood meta-analysis framework was used to model and understand the relationship between treatment effects and control group outcomes.Results:Under the informed model, an increase in control group WL of 1 kg corresponds with an expected shrinkage of the treatment effect by 0.309 kg (95% confidence interval (-0.480, -0.138), P=0.00081); this result is robust against violations of the model assumptions.Conclusions:We find that control conditions with large WLs diminish expected treatment effects. Our investigation may be helpful to clinicians as they design future WL/PWG studies.

Original languageEnglish
Pages (from-to)895-898
Number of pages4
JournalInternational Journal of Obesity
Volume40
Issue number6
DOIs
StatePublished - Jun 1 2016

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