Review/Preview: Prodrug Ionic Liquids

O A Cojocaru, Julia Shamshina, R D Rogers

Research output: Contribution to journalArticlepeer-review


A prodrug is an inactive derivative that is converted to the active drug in vivo through chemical and/or enzymatic transformations. The prodrug pharmaceutical strategy is a common approach used to overcome poor aqueous solubility, limited bioavailability, chemical instability, and/or poor permeability of active pharmaceutical ingredients (APIs). Ionic liquids (ILs) are salts with melting points or glass transition temperatures below 100°C, but in the context of APIs specifically below body temperature. The IL pharmaceutical strategy applied to readily ionisable drugs can be used to overcome disadvantages associated with the solid state of APIs, such as polymorphism or poor solubility/ bioavailability. By combining the IL strategy with the prodrug approach, IL forms of APIs can be further expanded to those APIs with non-ionisable or hard to ionise functional groups. Moreover, by making a prodrug into an IL, a second active might be introduced into the resulting salt (a dual functional
Original languageEnglish
Pages (from-to)7
JournalChimica Oggi - Chemistry Toda
StatePublished - 2013


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