Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle

Joaquin Gonzales; Stephen Fischer; Arun Maharaj; Heather Vellers; Todd Anderson; Adcharee Karnjanapiboonwong; Seenivasan Subbiah; J. Mikhail Kellawan; Arturo Figueroa-Galvez

Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle

Joaquin Gonzales, Stephen Fischer, Arun Maharaj, Heather Vellers, Todd Anderson, Adcharee Karnjanapiboonwong, Seenivasan Subbiah, J. Mikhail Kellawan, Arturo Figueroa-Galvez

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose To determine whether L-citrulline (CIT) supplementation during the follicular and luteal phases of the menstrual cycle would present differential effects on vasodilator kinetics in dynamically contracting muscle. Methods Twenty-four healthy young women not on oral contraceptives were studied during the follicular (n=13) and luteal phases (n=11). Supplementation with CIT (6g/day) or placebo occurred 7-days prior to the testing day in a crossover design across two menstrual cycles. Forearm vascular conductance (FVC) was calculated from blood flow and mean arterial pressure measured continuously during handgrip exercise performed at 10% maximal grip strength. FVC was calculated for each duty cycle (contract:relax, 1:2s) and expressed as a change from baseline (DFVC) before being fit with a monoexponential model. Amplitude of the DFVC response and the number of duty cycles for DFVC to reach 63% of steady-state amplitude (tDFVC) were derived from the model.<

Original language	English
Pages (from-to)	e14536
Journal	Physiological Reports
State	Published - Aug 2020

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Gonzales, Joaquin ; Fischer, Stephen ; Maharaj, Arun ; Vellers, Heather ; Anderson, Todd ; Karnjanapiboonwong, Adcharee ; Subbiah, Seenivasan ; Kellawan, J. Mikhail ; Figueroa-Galvez, Arturo. / Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle. In: Physiological Reports. 2020 ; pp. e14536.

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title = "Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle",

abstract = "Purpose To determine whether L-citrulline (CIT) supplementation during the follicular and luteal phases of the menstrual cycle would present differential effects on vasodilator kinetics in dynamically contracting muscle.Methods Twenty-four healthy young women not on oral contraceptives were studied during the follicular (n=13) and luteal phases (n=11). Supplementation with CIT (6g/day) or placebo occurred 7-days prior to the testing day in a crossover design across two menstrual cycles. Forearm vascular conductance (FVC) was calculated from blood flow and mean arterial pressure measured continuously during handgrip exercise performed at 10% maximal grip strength. FVC was calculated for each duty cycle (contract:relax, 1:2s) and expressed as a change from baseline (DFVC) before being fit with a monoexponential model. Amplitude of the DFVC response and the number of duty cycles for DFVC to reach 63% of steady-state amplitude (tDFVC) were derived from the model.<",

author = "Joaquin Gonzales and Stephen Fischer and Arun Maharaj and Heather Vellers and Todd Anderson and Adcharee Karnjanapiboonwong and Seenivasan Subbiah and Kellawan, {J. Mikhail} and Arturo Figueroa-Galvez",

year = "2020",

month = aug,

language = "English",

pages = "e14536",

journal = "Physiological Reports",

publisher = "The Physiological Society",

}

Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle. / Gonzales, Joaquin; Fischer, Stephen; Maharaj, Arun; Vellers, Heather ; Anderson, Todd; Karnjanapiboonwong, Adcharee; Subbiah, Seenivasan; Kellawan, J. Mikhail; Figueroa-Galvez, Arturo.

In: Physiological Reports, 08.2020, p. e14536.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle

AU - Gonzales, Joaquin

AU - Fischer, Stephen

AU - Maharaj, Arun

AU - Vellers, Heather

AU - Anderson, Todd

AU - Karnjanapiboonwong, Adcharee

AU - Subbiah, Seenivasan

AU - Kellawan, J. Mikhail

AU - Figueroa-Galvez, Arturo

PY - 2020/8

Y1 - 2020/8

N2 - Purpose To determine whether L-citrulline (CIT) supplementation during the follicular and luteal phases of the menstrual cycle would present differential effects on vasodilator kinetics in dynamically contracting muscle.Methods Twenty-four healthy young women not on oral contraceptives were studied during the follicular (n=13) and luteal phases (n=11). Supplementation with CIT (6g/day) or placebo occurred 7-days prior to the testing day in a crossover design across two menstrual cycles. Forearm vascular conductance (FVC) was calculated from blood flow and mean arterial pressure measured continuously during handgrip exercise performed at 10% maximal grip strength. FVC was calculated for each duty cycle (contract:relax, 1:2s) and expressed as a change from baseline (DFVC) before being fit with a monoexponential model. Amplitude of the DFVC response and the number of duty cycles for DFVC to reach 63% of steady-state amplitude (tDFVC) were derived from the model.<

AB - Purpose To determine whether L-citrulline (CIT) supplementation during the follicular and luteal phases of the menstrual cycle would present differential effects on vasodilator kinetics in dynamically contracting muscle.Methods Twenty-four healthy young women not on oral contraceptives were studied during the follicular (n=13) and luteal phases (n=11). Supplementation with CIT (6g/day) or placebo occurred 7-days prior to the testing day in a crossover design across two menstrual cycles. Forearm vascular conductance (FVC) was calculated from blood flow and mean arterial pressure measured continuously during handgrip exercise performed at 10% maximal grip strength. FVC was calculated for each duty cycle (contract:relax, 1:2s) and expressed as a change from baseline (DFVC) before being fit with a monoexponential model. Amplitude of the DFVC response and the number of duty cycles for DFVC to reach 63% of steady-state amplitude (tDFVC) were derived from the model.<