TY - JOUR
T1 - Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle
AU - Gonzales, Joaquin
AU - Fischer, Stephen
AU - Maharaj, Arun
AU - Vellers, Heather
AU - Anderson, Todd
AU - Karnjanapiboonwong, Adcharee
AU - Subbiah, Seenivasan
AU - Kellawan, J. Mikhail
AU - Figueroa-Galvez, Arturo
PY - 2020/8
Y1 - 2020/8
N2 - Purpose To determine whether L-citrulline (CIT) supplementation during the follicular and luteal phases of the menstrual cycle would present differential effects on vasodilator kinetics in dynamically contracting muscle.Methods Twenty-four healthy young women not on oral contraceptives were studied during the follicular (n=13) and luteal phases (n=11). Supplementation with CIT (6g/day) or placebo occurred 7-days prior to the testing day in a crossover design across two menstrual cycles. Forearm vascular conductance (FVC) was calculated from blood flow and mean arterial pressure measured continuously during handgrip exercise performed at 10% maximal grip strength. FVC was calculated for each duty cycle (contract:relax, 1:2s) and expressed as a change from baseline (DFVC) before being fit with a monoexponential model. Amplitude of the DFVC response and the number of duty cycles for DFVC to reach 63% of steady-state amplitude (tDFVC) were derived from the model.<
AB - Purpose To determine whether L-citrulline (CIT) supplementation during the follicular and luteal phases of the menstrual cycle would present differential effects on vasodilator kinetics in dynamically contracting muscle.Methods Twenty-four healthy young women not on oral contraceptives were studied during the follicular (n=13) and luteal phases (n=11). Supplementation with CIT (6g/day) or placebo occurred 7-days prior to the testing day in a crossover design across two menstrual cycles. Forearm vascular conductance (FVC) was calculated from blood flow and mean arterial pressure measured continuously during handgrip exercise performed at 10% maximal grip strength. FVC was calculated for each duty cycle (contract:relax, 1:2s) and expressed as a change from baseline (DFVC) before being fit with a monoexponential model. Amplitude of the DFVC response and the number of duty cycles for DFVC to reach 63% of steady-state amplitude (tDFVC) were derived from the model.<
M3 - Article
SP - e14536
JO - Physiological Reports
JF - Physiological Reports
ER -