Research on control of the cardiovascular system based on a left ventricular assist device

Fangqun Wang, Qing Xu, Zhenhai Wu, Taiyang Wen, Jinghua Ji, Zhaoming He

Research output: Contribution to journalArticlepeer-review


We propose a control model of the cardiovascular system coupled with a rotary blood pump in the present paper. A new mathematical model of the rotary heart pump is presented considering the hydraulic characteristics and the similarity principle of pumps. A seven-order nonlinear spatial state equation adopting lumped parameter is used to describe the combined cardiovascular-pump model. Pump speed is used as the control variable. To achieve sufficient perfusion and to avoid suction, a feedback strategy based on minimum (diastolic) pump flow is used in the control model. The results showed that left ventricular assist device (LVAD) could improve hemodynamics of the cardiovascular system of the patient with heart failure in open loop. When rotation speed was 9, 000 r/min, cardiac output reached 82 mL/s while the initial cardiac output was only 34 mL/s without the LVAD support. When the rotation speed was above 12 800 r/min, suction was found because the high rotating speed resulted in insufficient venous return volume. Suction was avoided by adopting the feedback control. The model reveals the interaction of LVAD and the cardiovascular system, which provides theoretical basis for the therapy of heart failure in the left ventricular and for the design of a physiological control strategy.

Original languageEnglish
Pages (from-to)1075-1083
Number of pages9
JournalShengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering
Issue number6
StatePublished - Dec 1 2016


  • Cardiovascular system
  • Feedback control
  • Heart failure
  • Left ventricular assist device
  • Suction


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