TY - JOUR
T1 - Research on control of the cardiovascular system based on a left ventricular assist device
AU - Wang, Fangqun
AU - Xu, Qing
AU - Wu, Zhenhai
AU - Wen, Taiyang
AU - Ji, Jinghua
AU - He, Zhaoming
N1 - Publisher Copyright:
� 2016, Editorial Office of Journal of Biomedical Engineering. All right reserved.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - We propose a control model of the cardiovascular system coupled with a rotary blood pump in the present paper. A new mathematical model of the rotary heart pump is presented considering the hydraulic characteristics and the similarity principle of pumps. A seven-order nonlinear spatial state equation adopting lumped parameter is used to describe the combined cardiovascular-pump model. Pump speed is used as the control variable. To achieve sufficient perfusion and to avoid suction, a feedback strategy based on minimum (diastolic) pump flow is used in the control model. The results showed that left ventricular assist device (LVAD) could improve hemodynamics of the cardiovascular system of the patient with heart failure in open loop. When rotation speed was 9, 000 r/min, cardiac output reached 82 mL/s while the initial cardiac output was only 34 mL/s without the LVAD support. When the rotation speed was above 12 800 r/min, suction was found because the high rotating speed resulted in insufficient venous return volume. Suction was avoided by adopting the feedback control. The model reveals the interaction of LVAD and the cardiovascular system, which provides theoretical basis for the therapy of heart failure in the left ventricular and for the design of a physiological control strategy.
AB - We propose a control model of the cardiovascular system coupled with a rotary blood pump in the present paper. A new mathematical model of the rotary heart pump is presented considering the hydraulic characteristics and the similarity principle of pumps. A seven-order nonlinear spatial state equation adopting lumped parameter is used to describe the combined cardiovascular-pump model. Pump speed is used as the control variable. To achieve sufficient perfusion and to avoid suction, a feedback strategy based on minimum (diastolic) pump flow is used in the control model. The results showed that left ventricular assist device (LVAD) could improve hemodynamics of the cardiovascular system of the patient with heart failure in open loop. When rotation speed was 9, 000 r/min, cardiac output reached 82 mL/s while the initial cardiac output was only 34 mL/s without the LVAD support. When the rotation speed was above 12 800 r/min, suction was found because the high rotating speed resulted in insufficient venous return volume. Suction was avoided by adopting the feedback control. The model reveals the interaction of LVAD and the cardiovascular system, which provides theoretical basis for the therapy of heart failure in the left ventricular and for the design of a physiological control strategy.
KW - Cardiovascular system
KW - Feedback control
KW - Heart failure
KW - Left ventricular assist device
KW - Suction
UR - http://www.scopus.com/inward/record.url?scp=85043413802&partnerID=8YFLogxK
U2 - 10.7507/1001-5515.20160172
DO - 10.7507/1001-5515.20160172
M3 - Article
C2 - 29714970
AN - SCOPUS:85043413802
SN - 1001-5515
VL - 33
SP - 1075
EP - 1083
JO - Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering
JF - Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering
IS - 6
ER -