Representation of Phase Equilibrium Behavior of Antibiotics

Yizu Zhu, Lawrence B. Evans, Chau‐Chyun ‐C Chen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The phase equilibrium behavior of biomolecules is important both in understanding the partition mechanisms and in the design and optimization of downstream recovery processes. Chen et al. (1989) proposed a molecular thermodynamic framework that successfully represents the liquid‐solid equilibrium behavior of amino acids and small peptides as functions of temperature, ionic strength, solvent compositions, and pH. Based on this theoretical framework, this paper presents recent results in representing the liquid‐solid equilibrium behavior (solubilities) and the liquid‐liquid equilibrium behavior (phase partitioning) of β‐lactam antibiotics, which are amino acid derivatives and important chemotherapeutic agents.

Original languageEnglish
Pages (from-to)266-272
Number of pages7
JournalBiotechnology Progress
Issue number4
StatePublished - 1990


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