TY - JOUR
T1 - Renin Angiotensin System Inhibition Attenuates Adipocyte-Breast Cancer Cell Interactions
AU - Fahmida, Rasha
AU - Ramalingam, Latha
AU - Menikdiwela, Kalhara Rashmikumara
AU - Hernandez, Arelys
AU - Moussa, Hanna
AU - Gollahon, Lauren
AU - Rakhshanda, Rahman L
AU - Moustaid-Moussa, Naima
PY - 2020/6
Y1 - 2020/6
N2 - Obesityisasignificantbreastcancer(BC)riskfactorandisassociatedwith20–40%increasedriskinobesepostmenopausalwomencomparedtotheirleancounterparts.Severalobesity-relatedmetabolicdysregulationshave beenlinkedtoBCrisk,includingoveractivationoftherenin-angiotensinsystem(RAS).Currently,RASinhibitors includingangiotensinconvertingenzymeinhibitor(ACEi)andAT1 receptorblockers(ARBs),areusedassafe and effective anti-hypertensive therapies in BC patients. However, it is uncertain how inhibition of RAS in adipose tissue impacts obesity-BC crosstalk. We hypothesized that adipose RAS inhibition will reduce BC cell motility and inflammation. We determined (1) the direct effects of Ang II, ACEi (captopril; Cap) or ARB (telmisartan;Tel)onreceptorpositiveMCF-7andreceptortriplenegativeMDA-MB-231cells;and(2)theeffectsof conditionedmedia(CM) fromhumanmesenchymalstemcellsdifferentiatedintoadipocytes,whichwerepretreatedwithRASinhibitors,onBCcells.WedemonstratedthatdirecttreatmentsofBCcellswithAngII,Capor Teldi
AB - Obesityisasignificantbreastcancer(BC)riskfactorandisassociatedwith20–40%increasedriskinobesepostmenopausalwomencomparedtotheirleancounterparts.Severalobesity-relatedmetabolicdysregulationshave beenlinkedtoBCrisk,includingoveractivationoftherenin-angiotensinsystem(RAS).Currently,RASinhibitors includingangiotensinconvertingenzymeinhibitor(ACEi)andAT1 receptorblockers(ARBs),areusedassafe and effective anti-hypertensive therapies in BC patients. However, it is uncertain how inhibition of RAS in adipose tissue impacts obesity-BC crosstalk. We hypothesized that adipose RAS inhibition will reduce BC cell motility and inflammation. We determined (1) the direct effects of Ang II, ACEi (captopril; Cap) or ARB (telmisartan;Tel)onreceptorpositiveMCF-7andreceptortriplenegativeMDA-MB-231cells;and(2)theeffectsof conditionedmedia(CM) fromhumanmesenchymalstemcellsdifferentiatedintoadipocytes,whichwerepretreatedwithRASinhibitors,onBCcells.WedemonstratedthatdirecttreatmentsofBCcellswithAngII,Capor Teldi
U2 - 10.3390/cancers12010220
DO - 10.3390/cancers12010220
M3 - Article
SP - 12
JO - Experimental Cell Research
JF - Experimental Cell Research
ER -