Renin Angiotensin System Inhibition Attenuates Adipocyte-Breast Cancer Cell Interactions

Rasha Fahmida; Latha Ramalingam; Kalhara Rashmikumara Menikdiwela; Arelys Hernandez; Hanna Moussa; Lauren Gollahon; Rahman L Rakhshanda; Naima Moustaid-Moussa

doi:10.3390/cancers12010220

Renin Angiotensin System Inhibition Attenuates Adipocyte-Breast Cancer Cell Interactions

Rasha Fahmida, Latha Ramalingam, Kalhara Rashmikumara Menikdiwela, Arelys Hernandez, Hanna Moussa, Lauren Gollahon, Rahman L Rakhshanda, Naima Moustaid-Moussa

Research output: Contribution to journal › Article › peer-review

Abstract

Obesityisasignificantbreastcancer(BC)riskfactorandisassociatedwith20–40%increasedriskinobesepostmenopausalwomencomparedtotheirleancounterparts.Severalobesity-relatedmetabolicdysregulationshave beenlinkedtoBCrisk,includingoveractivationoftherenin-angiotensinsystem(RAS).Currently,RASinhibitors includingangiotensinconvertingenzymeinhibitor(ACEi)andAT1 receptorblockers(ARBs),areusedassafe and effective anti-hypertensive therapies in BC patients. However, it is uncertain how inhibition of RAS in adipose tissue impacts obesity-BC crosstalk. We hypothesized that adipose RAS inhibition will reduce BC cell motility and inflammation. We determined (1) the direct effects of Ang II, ACEi (captopril; Cap) or ARB (telmisartan;Tel)onreceptorpositiveMCF-7andreceptortriplenegativeMDA-MB-231cells;and(2)theeffectsof conditionedmedia(CM) fromhumanmesenchymalstemcellsdifferentiatedintoadipocytes,whichwerepretreatedwithRASinhibitors,onBCcells.WedemonstratedthatdirecttreatmentsofBCcellswithAngII,Capor Teldi

Original language	English
Pages (from-to)	12
Journal	Experimental Cell Research
DOIs	https://doi.org/10.3390/cancers12010220
State	Published - Jun 2020

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@article{78c55f224d7c4313b2dc38fe92056db5,

title = "Renin Angiotensin System Inhibition Attenuates Adipocyte-Breast Cancer Cell Interactions",

abstract = "Obesityisasignificantbreastcancer(BC)riskfactorandisassociatedwith20–40%increasedriskinobesepostmenopausalwomencomparedtotheirleancounterparts.Severalobesity-relatedmetabolicdysregulationshave beenlinkedtoBCrisk,includingoveractivationoftherenin-angiotensinsystem(RAS).Currently,RASinhibitors includingangiotensinconvertingenzymeinhibitor(ACEi)andAT1 receptorblockers(ARBs),areusedassafe and effective anti-hypertensive therapies in BC patients. However, it is uncertain how inhibition of RAS in adipose tissue impacts obesity-BC crosstalk. We hypothesized that adipose RAS inhibition will reduce BC cell motility and inflammation. We determined (1) the direct effects of Ang II, ACEi (captopril; Cap) or ARB (telmisartan;Tel)onreceptorpositiveMCF-7andreceptortriplenegativeMDA-MB-231cells;and(2)theeffectsof conditionedmedia(CM) fromhumanmesenchymalstemcellsdifferentiatedintoadipocytes,whichwerepretreatedwithRASinhibitors,onBCcells.WedemonstratedthatdirecttreatmentsofBCcellswithAngII,Capor Teldi",

author = "Rasha Fahmida and Latha Ramalingam and Menikdiwela, {Kalhara Rashmikumara} and Arelys Hernandez and Hanna Moussa and Lauren Gollahon and Rakhshanda, {Rahman L} and Naima Moustaid-Moussa",

year = "2020",

month = jun,

doi = "10.3390/cancers12010220",

language = "English",

pages = "12",

journal = "Experimental Cell Research",

publisher = "Elsevier",

}

Renin Angiotensin System Inhibition Attenuates Adipocyte-Breast Cancer Cell Interactions. / Fahmida, Rasha; Ramalingam, Latha; Menikdiwela, Kalhara Rashmikumara; Hernandez, Arelys; Moussa, Hanna ; Gollahon, Lauren; Rakhshanda, Rahman L; Moustaid-Moussa, Naima.

In: Experimental Cell Research, 06.2020, p. 12.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Renin Angiotensin System Inhibition Attenuates Adipocyte-Breast Cancer Cell Interactions

AU - Fahmida, Rasha

AU - Ramalingam, Latha

AU - Menikdiwela, Kalhara Rashmikumara

AU - Hernandez, Arelys

AU - Moussa, Hanna

AU - Gollahon, Lauren

AU - Rakhshanda, Rahman L

AU - Moustaid-Moussa, Naima

PY - 2020/6

Y1 - 2020/6

N2 - Obesityisasignificantbreastcancer(BC)riskfactorandisassociatedwith20–40%increasedriskinobesepostmenopausalwomencomparedtotheirleancounterparts.Severalobesity-relatedmetabolicdysregulationshave beenlinkedtoBCrisk,includingoveractivationoftherenin-angiotensinsystem(RAS).Currently,RASinhibitors includingangiotensinconvertingenzymeinhibitor(ACEi)andAT1 receptorblockers(ARBs),areusedassafe and effective anti-hypertensive therapies in BC patients. However, it is uncertain how inhibition of RAS in adipose tissue impacts obesity-BC crosstalk. We hypothesized that adipose RAS inhibition will reduce BC cell motility and inflammation. We determined (1) the direct effects of Ang II, ACEi (captopril; Cap) or ARB (telmisartan;Tel)onreceptorpositiveMCF-7andreceptortriplenegativeMDA-MB-231cells;and(2)theeffectsof conditionedmedia(CM) fromhumanmesenchymalstemcellsdifferentiatedintoadipocytes,whichwerepretreatedwithRASinhibitors,onBCcells.WedemonstratedthatdirecttreatmentsofBCcellswithAngII,Capor Teldi

AB - Obesityisasignificantbreastcancer(BC)riskfactorandisassociatedwith20–40%increasedriskinobesepostmenopausalwomencomparedtotheirleancounterparts.Severalobesity-relatedmetabolicdysregulationshave beenlinkedtoBCrisk,includingoveractivationoftherenin-angiotensinsystem(RAS).Currently,RASinhibitors includingangiotensinconvertingenzymeinhibitor(ACEi)andAT1 receptorblockers(ARBs),areusedassafe and effective anti-hypertensive therapies in BC patients. However, it is uncertain how inhibition of RAS in adipose tissue impacts obesity-BC crosstalk. We hypothesized that adipose RAS inhibition will reduce BC cell motility and inflammation. We determined (1) the direct effects of Ang II, ACEi (captopril; Cap) or ARB (telmisartan;Tel)onreceptorpositiveMCF-7andreceptortriplenegativeMDA-MB-231cells;and(2)theeffectsof conditionedmedia(CM) fromhumanmesenchymalstemcellsdifferentiatedintoadipocytes,whichwerepretreatedwithRASinhibitors,onBCcells.WedemonstratedthatdirecttreatmentsofBCcellswithAngII,Capor Teldi

U2 - 10.3390/cancers12010220

DO - 10.3390/cancers12010220

M3 - Article

SP - 12

JO - Experimental Cell Research

JF - Experimental Cell Research

ER -