Renin Angiotensin System Inhibition Attenuates Adipocyte-Breast Cancer Cell Interactions

Rasha Fahmida, Latha Ramalingam, Kalhara Rashmikumara Menikdiwela, Arelys Hernandez, Hanna Moussa, Lauren Gollahon, Rahman L Rakhshanda, Naima Moustaid-Moussa

Research output: Contribution to journalArticlepeer-review

Abstract

Obesityisasignificantbreastcancer(BC)riskfactorandisassociatedwith20–40%increasedriskinobesepostmenopausalwomencomparedtotheirleancounterparts.Severalobesity-relatedmetabolicdysregulationshave beenlinkedtoBCrisk,includingoveractivationoftherenin-angiotensinsystem(RAS).Currently,RASinhibitors includingangiotensinconvertingenzymeinhibitor(ACEi)andAT1 receptorblockers(ARBs),areusedassafe and effective anti-hypertensive therapies in BC patients. However, it is uncertain how inhibition of RAS in adipose tissue impacts obesity-BC crosstalk. We hypothesized that adipose RAS inhibition will reduce BC cell motility and inflammation. We determined (1) the direct effects of Ang II, ACEi (captopril; Cap) or ARB (telmisartan;Tel)onreceptorpositiveMCF-7andreceptortriplenegativeMDA-MB-231cells;and(2)theeffectsof conditionedmedia(CM) fromhumanmesenchymalstemcellsdifferentiatedintoadipocytes,whichwerepretreatedwithRASinhibitors,onBCcells.WedemonstratedthatdirecttreatmentsofBCcellswithAngII,Capor Teldi
Original languageEnglish
Pages (from-to)12
JournalExperimental Cell Research
DOIs
StatePublished - Jun 2020

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