Remarkable decrease in stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry

Kristin M. Hutchins, Thilini P. Rupasinghe, Shalisa M. Oburn, Kamal K. Ray, Alexei V. Tivanski, Leonard R. MacGillivray

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Nano-dimensional single crystals of acetylsalicylic acid (aspirin) Form I are generated through sonocrystallization and are shown to exhibit Young's modulus values in the MPa range, which is significantly softer (5-fold reduction) than macro-dimensional single crystals. The change is attributed to structural consequences of the size-dependent surface-to-volume ratio effect, particularly as related to intermolecular forces.

Original languageEnglish
Pages (from-to)2049-2052
Number of pages4
JournalCrystEngComm
Volume21
Issue number13
DOIs
StatePublished - 2019

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