Regulation of isopentenoid biosynthesis by plant growth retardants in Nicotiana tabacum

W. David Nes, Trevor J. Douglas, Jiann Tsyh Lin, Erich Heftmann, Leslie G. Paleg

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17 Scopus citations


The effects of AMO-1618, AY-9944 and SKF-7997 on the growth of Nicotiana tabacum and on the biosynthesis of acidic and neutral isopentenoids in the seedlings were examined. All three compounds significantly retarded stem elongation but not dry wt of the plants. Incorporation of radioactivity from [2- 14C]-mevalonate into acidic and neutral isopentenoids showed a direct relationship between the radioactivity in the two fractions and stem growth. All three compounds inhibited steps before as well as after squalene formation, but the acylic and polycyclic isopentenoids which accumulated as a result of the inhibition were not necessarily the same in each of the treatment groups. This indicates that stem growth is probably influenced not by a single product of isopentenoid biosynthesis, but rather by several products, which may even act independently in their effects on developmental processes.

Original languageEnglish
Pages (from-to)575-579
Number of pages5
Issue number3
StatePublished - 1982


  • 2,3-oxidosqualene.
  • Nicotiana tabacum
  • Solanaceae
  • gibberellins
  • growth retardants
  • isopentenoid biosynthesis
  • sterols


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